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    Article

    Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity

    The molecular basis for the propensity of a small number of environmental proteins to provoke allergic responses is largely unknown. Herein, we report that mite group 13 allergens of the fatty acid-binding pro...

    Ursula Smole, Naina Gour, Jordan Phelan, Gerhard Hofer, Cordula Köhler in Nature Immunology (2020)

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    Epithelial Cell Regulation of Allergic Diseases

    Allergic diseases, which have escalated in prevalence in recent years, arise as a result of maladaptive immune responses to ubiquitous environmental stimuli. Why only certain individuals mount inappropriate ty...

    Naina Gour, Stephane Lajoie in Current Allergy and Asthma Reports (2016)

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    Article

    Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma

    Greater production of interleukin 17A is associated with severe asthma. Wills-Karp and colleagues show that the complement anaphylatoxins C3a and C5a have opposing roles in enhancing or suppressing IL-17a in a...

    Stephane Lajoie, Ian P Lewkowich, Yusuke Suzuki, Jennifer R Clark in Nature Immunology (2010)