63 Result(s)

Article

Venetoclax resistance in acute lymphoblastic leukemia is characterized by increased mitochondrial activity and can be overcome by co-targeting oxidative phosphorylation

Deregulated apoptosis signaling is characteristic for many cancers and contributes to leukemogenesis and treatment failure in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Apoptosis is controlled by...

Stefanie Enzenmüller, Alexandra Niedermayer, Felix Seyfried… in Cell Death & Disease (2024)

Article

Impairment of α-tubulin and F-actin interactions of GJB3 induces aneuploidy in urothelial cells and promotes bladder cancer cell invasion

We have previously identified an unsuspected role for GJB3 showing that the deficiency of this connexin protein induces aneuploidy in human and murine cells and accelerates cell transformation as well as tumor...

Junnan Liu, Xue Wang, Wencheng Jiang, Anca Azoitei… in Cellular & Molecular Biology Letters (2024)

Article

ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia—2024 update

In chronic lymphocytic leukemia (CLL), analysis of TP53 aberrations (deletion and/or mutation) is a crucial part of treatment decision-making algorithms. Technological and treatment advances have resulted in the ...

Jitka Malcikova, Sarka Pavlova, Panagiotis Baliakas, Thomas Chatzikonstantinou… in Leukemia (2024)

Article

The addition of bortezomib to rituximab, high-dose cytarabine and dexamethasone in relapsed or refractory mantle cell lymphoma—a randomized, open-label phase III trial of the European mantle cell lymphoma network

The therapy of relapsed or refractory (r/r) mantle cell lymphoma (MCL) patients remains a major clinical challenge to date. We conducted a randomized, open-label, parallel-group phase-III trial hypothesizing s...

Luca Fischer, Linmiao Jiang, Jan Dürig, Christian Schmidt, Stephan Stilgenbauer… in Leukemia (2024)

Article

Tislelizumab plus zanubrutinib for Richter transformation: the phase 2 RT1 trial

In patients with chronic lymphocytic leukemia, Richter transformation (RT) reflects the development of an aggressive lymphoma that is associated with poor response to chemotherapy and short survival. We initia...

Othman Al-Sawaf, Rudy Ligtvoet, Sandra Robrecht, Janina Stumpf… in Nature Medicine (2024)

Article

Author Correction: Transcriptomic profiles and 5-year results from the randomized CLL14 study of venetoclax plus obinutuzumab versus chlorambucil plus obinutuzumab in chronic lymphocytic leukemia

Othman Al-Sawaf, Can Zhang, Hyun Yong **, Sandra Robrecht… in Nature Communications (2023)

Article

Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics

We have recently shown that loss of ORP3 leads to aneuploidy induction and promotes tumor formation. However, the specific mechanisms by which ORP3 contributes to ploidy-control and cancer initiation and progr...

Xue Wang, Junnan Liu, Anca Azoitei, Tim Eiseler… in Cellular and Molecular Life Sciences (2023)

Article

Profile of the multicenter cohort of the German Cancer Consortium’s Clinical Communication Platform

Treatment concepts in oncology are becoming increasingly personalized and diverse. Successively, changes in standards of care mandate continuous monitoring of patient pathways and clinical outcomes based on la...

Daniel Maier, Jörg Janne Vehreschild, Barbara Uhl… in European Journal of Epidemiology (2023)

Article

Transcriptomic profiles and 5-year results from the randomized CLL14 study of venetoclax plus obinutuzumab versus chlorambucil plus obinutuzumab in chronic lymphocytic leukemia

Data on long-term outcomes and biological drivers associated with depth of remission after BCL2 inhibition by venetoclax in the treatment of chronic lymphocytic leukemia (CLL) are limited. In this open-label p...

Othman Al-Sawaf, Can Zhang, Hyun Yong **, Sandra Robrecht… in Nature Communications (2023)

Article

Cancer care in German centers of excellence during the first 2 years of the COVID-19 pandemic

An increasing number of international studies demonstrate serious negative effects of the COVID-19 pandemic on the timely diagnosis of cancer and on cancer treatment. Our study aimed to quantitatively and qual...

Volker Arndt, Daniela Doege, Stefan Fröhling… in Journal of Cancer Research and Clinical On… (2023)

Article

Molecular characterization of Richter syndrome identifies de novo diffuse large B-cell lymphomas with poor prognosis

Richter syndrome (RS) is the transformation of chronic lymphocytic leukemia (CLL) into aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL). We characterize 58 primary human RS samples by g...

Julien Broséus, Sébastien Hergalant, Julia Vogt, Eugen Tausch… in Nature Communications (2023)

Article

Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape

Hotspot mutations in the PEST-domain of NOTCH1 and NOTCH2 are recurrently identified in B cell malignancies. To address how NOTCH-mutations contribute to a dismal prognosis, we have generated isogenic primary hum...

Maurizio Mangolini, Alba Maiques-Diaz, Stella Charalampopoulou… in Nature Communications (2022)

Article

Proteogenomics refines the molecular classification of chronic lymphocytic leukemia

Cancer heterogeneity at the proteome level may explain differences in therapy response and prognosis beyond the currently established genomic and transcriptomic-based diagnostics. The relevance of proteomics f...

Sophie A. Herbst, Mattias Vesterlund, Alexander J. Helmboldt… in Nature Communications (2022)

Article

Sequential treatment with bendamustine, obinutuzumab (GA101) and Ibrutinib in chronic lymphocytic leukemia (CLL): final results of the CLL2-BIG trial

Julia von Tresckow, Paula Cramer, Sandra Robrecht, Petra Langerbeins… in Leukemia (2022)

Article

The scaffold protein NEDD9 is necessary for leukemia-cell migration and disease progression in a mouse model of chronic lymphocytic leukemia

The scaffold protein NEDD9 is frequently upregulated and hyperphosphorylated in cancers, and is associated with poor clinical outcome. NEDD9 promotes B-cell adhesion, migration and chemotaxis, pivotal processe...

Lisa Rusyn, Sebastian Reinartz, Anastasia Nikiforov, Nelly Mikhael… in Leukemia (2022)

Article

Longitudinal analyses of CLL in mice identify leukemia-related clonal changes including a Myc gain predicting poor outcome in patients

Chronic lymphocytic leukemia (CLL) is a B-cell malignancy mainly occurring at an advanced age with no single major genetic driver. Transgenic expression of TCL1 in B cells leads after a long latency to a CLL-like...

Selcen Öztürk, Yashna Paul, Saira Afzal, Irene Gil-Farina, Anna Jauch… in Leukemia (2022)

Article

Correction to: Allogeneic hematopoietic cell transplantation for patients with TP53 mutant or deleted chronic lymphocytic leukemia: results of a prospective observational study

Johannes Schetelig, Jennifer Hoek, Stephan Stilgenbauer… in Bone Marrow Transplantation (2022)