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Chapter
Biological Significance of Tumor Gangliosides: Shedding, Transfer, and Immunosuppression
Tumor formation is a complex, multiple-step process influenced by many factors. Local interactions between the tumor cell and the host are critical to tumor formation, and it is becoming recognized that the re...
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Article
Structural characterization andin vivo immunosuppressive activity of neuroblastoma GD2
Shedding of neuroblastoma gangliosides is positively correlated with tumour progression in patients with neuroblastoma. In assessing the biological activity of these ganglioside molecules, we recently found th...
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Article
Induction of GM1a/GD1b synthase triggers complex ganglioside expression and alters neuroblastoma cell behavior; a new tumor cell model of ganglioside function
Neuroblastoma is the most common extracranial solid tumor in children and tumor ganglioside composition has been linked to its biological and clinical behavior. We recently found that high expression of comple...