Page
%P
-
Article
Open AccessUrban Scaling Functions: Emission, Pollution and Health
Urban scaling is widely used to characterize the population dependence of city indicators including greenhouse gas emission. Here we analyze the population dependence of CO
-
Article
Open AccessHarnessing deep learning to forecast local microclimate using global climate data
Microclimate is a complex non-linear phenomenon influenced by both global and local processes. Its understanding holds a pivotal role in the management of natural resources and the optimization of agricultural...
-
Article
Disordered mechanical metamaterials
Mechanical metamaterials are a class of artificial materials whose geometry is engineered to have peculiar mechanical properties or programmed responses that are difficult to find in conventional materials. Ty...
-
Article
Open AccessInterrogating colorectal cancer metastasis to liver: a search for clinically viable compounds and mechanistic insights in colorectal cancer Patient Derived Organoids
Approximately 20–50% of patients presenting with localized colorectal cancer progress to stage IV metastatic disease (mCRC) following initial treatment and this is a major prognostic determinant. Here, we have...
-
Article
Open AccessClassification of triple negative breast cancer by epithelial mesenchymal transition and the tumor immune microenvironment
Triple-negative breast cancer (TNBC) accounts for about 15–20% of all breast cancers and differs from other invasive breast cancer types because it grows and spreads rapidly, it has limited treatment options a...
-
Article
Open AccessPredicting the failure of two-dimensional silica glasses
Being able to predict the failure of materials based on structural information is a fundamental issue with enormous practical and industrial relevance for the monitoring of devices and components. Thanks to re...
-
Article
Open AccessFrom mechanism-based to data-driven approaches in materials science
A time-honored approach in theoretical materials science revolves around the search for basic mechanisms that should incorporate key feature of the phenomenon under investigation. Recent years have witnessed a...
-
Article
Open AccessSynergistic effects of contaminants in Lombardy waters
Quantifying synergistic environmental effects in water contamination is still an open issue. Here, we have analyzed geolocalized data of pollutants recorded in 2018 in surface and groundwater of Lombardy, one ...
-
Article
Open AccessOral mucositis: the hidden side of cancer therapy
Inflammation response of epithelial mucosa to chemo- radiotherapy cytotoxic effects leads to mucositis, a painful side effect of antineoplastic treatments. About 40% of the patients treated with chemotherapy d...
-
Article
Phase transitions in cell migration
Phase transitions from a static to a moving phase are observed in a variety of physical systems and are thought to play a key role in cellular assemblies such as healthy and cancerous tissue. Caterina La Porta...
-
Article
Cell–cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion
Plasticity of cancer invasion and metastasis depends on the ability of cancer cells to switch between collective and single-cell dissemination, controlled by cadherin-mediated cell–cell junctions. In clinical ...
-
Article
Open AccessAutomatic design of mechanical metamaterial actuators
Mechanical metamaterial actuators achieve pre-determined input–output operations exploiting architectural features encoded within a single 3D printed element, thus removing the need for assembling different st...
-
Article
Open AccessAuthor Correction: Identifying inhibitors of epithelial–mesenchymal plasticity using a network topology-based approach
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Open AccessIdentifying inhibitors of epithelial–mesenchymal plasticity using a network topology-based approach
Metastasis is the cause of over 90% of cancer-related deaths. Cancer cells undergoing metastasis can switch dynamically between different phenotypes, enabling them to adapt to harsh challenges, such as overcom...
-
Chapter
Exaptation in Physics and Materials Science
The biological theory of evolution has been used as a powerful analogy for the history of technological . Here, we discuss how the concept of exaptation, which in the context of evolutionary biology describes th...
-
Article
Cross-Talk Between circRNAs and mRNAs Modulates MiRNA-mediated Circuits and Affects Melanoma Plasticity
CircularRNAs (circRNAs) are non-coding RNAs which compete for microRNA (miRNA) binding, influencing the abundance and stability of other RNA species. Herein we have investigated the effect of circRNAs on the m...
-
Article
Open AccessMolecular mechanisms of heterogeneous oligomerization of huntingtin proteins
There is still no successful strategy to treat Huntington’s disease, an inherited autosomal disorder associated with the aggregation of mutated forms of the huntingtin protein containing polyglutamine tracts w...
-
Book
-
Chapter
Statistical Features of Collective Cell Migration
We discuss recent advances in interpreting the collective dynamics of cellular assemblies using ideas and tools coming from the statistical physics of materials. Experimental observations suggest analogies bet...
-
Chapter
Surface Nano-structured Coating for Improved Performance of Axial Piston Pumps
The work starts from the consideration that most of the power losses in a hydraulic pump is due to frictional losses made by the relative motion between moving parts. This fact is particularly true at low oper...
