-
Article
Open AccessAuthor Correction: Type of adjuvant endocrine therapy and disease-free survival in patients with early HR-positive/HER2-positive BC: analysis from the phase III randomized ShortHER trial
-
Article
Open AccessType of adjuvant endocrine therapy and disease-free survival in patients with early HR-positive/HER2-positive BC: analysis from the phase III randomized ShortHER trial
The optimal adjuvant endocrine therapy for HR-positive/HER2-positive breast cancer patients is unknown. We included in this analysis 784 patients with HR-positive/HER2-positive BC from the randomized ShortHER ...
-
Article
Machine learning in neuro-oncology: toward novel development fields
Artificial Intelligence (AI) involves several and different techniques able to elaborate a large amount of data responding to a specific planned outcome. There are several possible applications of this technol...
-
Article
Pharmacotherapeutic Treatment of Glioblastoma: Where Are We to Date?
The clinical management of glioblastoma (GBM) is still bereft of treatments able to significantly improve the poor prognosis of the disease. Despite the extreme clinical need for novel therapeutic drugs, only ...
-
Article
Clinical and Molecular Features of Patients with Gliomas Harboring IDH1 Non-canonical Mutations: A Systematic Review and Meta-Analysis
The canonical isocitrate dehydrogenase 1 R132 mutation (IDH1 R132) is the most frequent mutation among IDH-mutated gliomas. Non-canonical IDH1 mutations or IDH2 mutations are unusual and their clinical and biolog...
-
Article
Is Molecular Tailored-Therapy Changing the Paradigm for CNS Metastases in Breast Cancer?
Breast cancer (BC) is the second most common tumour spreading to the central nervous system (CNS). The prognosis of patients with CNS metastases depends on several parameters including the molecular assessment...
-
Chapter
Probabilistic E-tools for Hazard Assessment and Risk Management
The impact of a natural event can significantly affect human life and the environment. Although fascinating, a volcanic eruption creates similar or even greater problems than more frequent natural events due t...
-
Article
Third-line therapy in recurrent glioblastoma: is it another chance for bevacizumab?
Standard glioblastoma therapy is long-lasting. Among second-line therapy, choices could be bevacizumab and nitrosoureas depending on National Agencies approval. There is no consensus on 3rd line therapy or cli...
-
Article
Open AccessSusceptibility of intrusion-related landslides at volcanic islands: the Stromboli case study
Susceptibility of intrusion-related landslides in an active volcano was evaluated coupling the landslide susceptibility estimation by random forest (RF), and the probabilistic volcanic vent opening distributio...
-
Article
Historic hydrovolcanism at Deception Island (Antarctica): implications for eruption hazards
Deception Island (Antarctica) is the southernmost island of the South Shetland Archipelago in the South Atlantic. Volcanic activity since the eighteenth century, along with the latest volcanic unrest episodes ...
-
Article
A scale for ranking volcanoes by risk
We propose a simple volcanic risk coefficient (VRC) useful for comparing the degree of risk arising from different volcanoes, which may be used by civil protection agencies and volcano observatories to rapidly...
-
Article
Hazard assessment at the Quaternary La Garrotxa Volcanic Field (NE Iberia)
La Garrotxa Volcanic Field (GVF) in the NE Iberian Peninsula is one of the Quaternary alkaline volcanic provinces that form part of the European Cenozoic Rift System. Active over the last 0.7 Ma, the most rece...
-
Article
Post progression survival in glioblastoma: where are we?
The optimal end point for phase II studies for recurrent glioblastoma (GBM) is unclear and a matter of debate. Moreover, data about post-progression survival (PPS) after the first disease progression in GBM pa...
-
Article
Open AccessHASSET: a probability event tree tool to evaluate future volcanic scenarios using Bayesian inference
Event tree structures constitute one of the most useful and necessary tools in modern volcanology for assessment of hazards from future volcanic scenarios (those that culminate in an eruptive event as well as ...
