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Article
Open AccessPlacing vacuum sponges in esophageal anastomotic leaks — how we do it
Endoluminal vacuum sponge therapy has dramatically improved the treatment of anastomotic leaks in esophageal surgery. However, the blind insertion of vacuum sponge kits like Eso-Sponge® via an overtube and a p...
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Article
Open AccessSeismic anisotropy of Opalinus Clay: tomographic investigations using the infrastructure of an underground rock laboratory (URL)
Seismic anisotropy and attenuation make claystone formations difficult to characterize. On the other hand, in many geotechnical environments, precise knowledge of structure and elastic properties of clay forma...
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Article
Open AccessClinical and endoscopic characteristics of diffuse esophageal intramural pseudo-diverticulosis
With 250 published cases worldwide, diffuse esophageal intramural pseudo-diverticulosis (DEIPD) is a poorly understood disease. The aim of this study was to determine the prevalence of DEIPD in our own populat...
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Article
Open AccessHigh rates of cirrhosis and severe clinical events in patients with HBV/HDV co-infection: longitudinal analysis of a German cohort
Chronic hepatitis delta virus (HDV) infection causes severe liver disease which often leads to cirrhosis and hepatocellular carcinoma (HCC). Aim of this study was to establish the disease severity and prognost...
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Article
Open AccessPharmacokinetic and Pharmacodynamic Properties of l-Ornithine l-Aspartate (LOLA) in Hepatic Encephalopathy
l-Ornithine l-aspartate (LOLA), a stable salt of l-ornithine and l-aspartate, readily dissociates into its constituent amino acids that are readily absorbed by active transport, distributed, and metabolized. l-or...
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Article
Open AccessComplement factors C3a and C5a mimick a proinflammatory microenvironment and increase HBV IGRA sensitivity
Hepatitis B virus (HBV) infections represent a global health problem and chronic hepatitis B (CHB) leads to liver cirrhosis and hepatocellular carcinoma. Thus, timely diagnosis of hepatitis B is crucial to ens...
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Article
Autoantibodies against “rods and rings”-related IMPDH2 in hepatitis C genotype 1 and DAA therapy in a “real life” cohort
Autoantibodies against inosine-5′-monophosphate-dehydrogenase-2 (IMPDH2; “rods and rings” pattern) develop in chronic hepatitis C (CHC) patients under treatment with peg-interferon (IFN) and ribavirin (RBV), a...
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Chapter
Field Injection Operations and Monitoring of the Injected CO2
Monitoring the fate of the injected CO2 and possible associated effects, such as and chemical effects in the target reservoir and its surroundings, is essential for safe operation of a storage facility. In this ...
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Article
Open AccessCRISPR/Cas9 nickase-mediated disruption of hepatitis B virus open reading frame S and X
Current antiviral therapies cannot cure hepatitis B virus (HBV) infection; successful HBV eradication would require inactivation of the viral genome, which primarily persists in host cells as episomal covalent...
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Article
Open AccessDevelopment of a novel IGRA assay to test T cell responsiveness to HBV antigens in whole blood of chronic Hepatitis B patients
Interferon gamma release assays (IGRA) have been developed to support easy and fast diagnosis of diseases like tuberculosis, and CMV in transplant patients. IGRAs focus on cellular immunity especially memory T...
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Chapter
Joint Research Project CO2MAN (CO2MAN Reservoir Management): Continuation of Research and Development Work for CO2 Storage at the Ketzin Pilot Site
The joint project CO2MAN (CO2 Reservoir Management) was a scientific programme accompanying geological CO2 storage at the Ketzin pilot site in the German Federal State of Brandenburg. The project which was funded...
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Article
Open AccessGerman cohort of HCV mono-infected and HCV/HIV co-infected patients reveals relative under-treatment of co-infected patients
Current German and European HIV guidelines recommend early evaluation of HCV treatment in all HIV/HCV co-infected patients. However, there are still considerable barriers to initiate HCV therapy in everyday cl...
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Article
Open AccessSafety and efficacy of protease inhibitor based combination therapy in a single-center “real-life” cohort of 110 patients with chronic hepatitis C genotype 1 infection
The combination of boceprevir or telaprevir with peginterferon-alfa and ribavirin for the treatment of patients infected with HCV genotype 1 has led to significantly increased rates of sustained virological re...
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Chapter
Toolbox for Applied Seismic Tomography (TOAST)
TOAST (Toolbox for Applied Seismic Tomography) makes methods of full-waveform inversion of elastic waves available for the practitioner. The inversion of complete seismograms is an utmost ambitious and powerfu...
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Chapter
Seismic Tomography and Monitoring in Underground Structures: Developments in the Freiberg Reiche Zeche Underground Lab (Freiberg, Germany) and Their Application in Underground Construction (SOUND)
The construction of large tunnels and underground infrastructures faces increasingly large dimensions and complex geological conditions. Under these conditions, exploration techniques are needed which enable f...
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Chapter
Autoimmune hepatitis in humans
Autoimmune hepatitis (AIH) can occur in all age groups from earliest childhood up until the 8th decade. AIH affects women more commonly than men (3:1). Clinical presentation may be an acute hepatitis up to ful...
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Chapter
Seismic Images of Accretive and Erosive Subduction Zones from the Chilean Margin
Modern seismic imaging methods were used to study the subduction processes of the South American convergent margin. The data came from reflection and from wide-angle/refraction experiments acquired within the ...
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Chapter
Geophysical Signatures and Active Tectonics at the South-Central Chilean Margin
The ISSA 2000 (Integrated Seismological experiment in the Southern Andes) and SPOC 2001 (Subduction Processes Off Chile) onshore and offshore projects surveyed the Chilean margin between 36 and 40° S. This are...
