12 Result(s)
within
Stefan Bauer
Biomedicine
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Article
Causal machine learning for predicting treatment outcomes
Causal machine learning (ML) offers flexible, data-driven methods for predicting treatment outcomes including efficacy and toxicity, thereby supporting the assessment and safety of drugs. A key benefit of caus...
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Article
Open AccessAdjuvant formulated virus-like particles expressing native-like forms of the Lassa virus envelope surface glycoprotein are immunogenic and induce antibodies with broadly neutralizing activity
Lassa mammarenavirus (LASV) is a rodent-borne arenavirus endemic to several West African countries. It is the causative agent of human Lassa fever, an acute viral hemorrhagic fever disease. To date, no therapeuti...
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Protocol
Detection of RNA Modifications by HPLC Analysis and Competitive ELISA
Over 100 different RNA modifications exist that are introduced posttranscriptionally by enzymes at specific nucleotide positions. Ribosomal RNA (rRNA) and transfer RNA (tRNA) exhibit the most and diverse modif...
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Chapter
Atlas-Based Segmentation of Tumor-Bearing Brain Images
In diagnostic neuroradiology as well as in radiation oncology and neurosurgery, there is an increasing demand for accurate segmentation of tumor-bearing brain images. Atlas-based segmentation is an appealing a...
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Article
Automatic Scan Planning for Magnetic Resonance Imaging of the Knee Joint
Automatic scan planning for magnetic resonance imaging of the knee aims at defining an oriented bounding box around the knee joint from sparse scout images in order to choose the optimal field of view for the ...
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Protocol
Cloning and Expression of Hemicellulases from Aspergillus nidulans in Pichia pastoris
The methylotrophic yeast Pichia pastoris is increasingly used for heterologous expression of high quality proteins in laboratory-scale (milligram) quantities. Commercially available polysaccharide-active enzyme p...
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Chapter
Pattern Recognition by Toll-like Receptors
The mammalian immune system senses pathogens through pattern recognition receptors and responds with activation. The Toll-like receptors (TLRs) that are expressed on antigen presenting cells such as macrophage...
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Chapter
TLR9-Mediated Recognition of DNA
The mammalian immune system senses pathogens through pattern recognition receptors (PRRs) and responds with activation. The Toll-like receptor (TLR) family that consists of 13 receptors plays a critical role i...
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Article
Toll-erating self DNA
Discrimination between self and bacterial DNA has been attributed in part to differential modification of prokaryotic and eukaryotic DNA. However, cellular localization of innate DNA receptors may be even more...
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Article
Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease
Autoimmune diabetes mellitus in humans is characterized by immunological destruction of pancreatic beta islet cells. We investigated the circumstances under which CD8+ T cells specific for pancreatic beta-islet a...
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Article
Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
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Article
Crystal structure of the murine NK cell–activating receptor NKG2D at 1.95 Å
NKG2D, a homodimeric lectin-like receptor, is a unique stimulatory molecule that is found on natural killer cells, T cells and activated macrophages. The natural ligands for murine NKG2D are distant major hist...
