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  1. Article

    Open Access

    Effects of SPI1-mediated transcriptome remodeling on Alzheimer’s disease-related phenotypes in mouse models of Aβ amyloidosis

    SPI1 was recently reported as a genetic risk factor for Alzheimer’s disease (AD) in large-scale genome-wide association studies. However, it is unknown whether SPI1 should be downregulated or increased to have th...

    Byungwook Kim, Luke Child Dabin, Mason Douglas Tate, Hande Karahan… in Nature Communications (2024)

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  2. Article

    Open Access

    Contribution of rare homozygous and compound heterozygous VPS13C missense mutations to dementia with Lewy bodies and Parkinson’s disease

    Dementia with Lewy bodies (DLB) and Parkinson’s disease (PD) are clinically, pathologically and etiologically disorders embedded in the Lewy body disease (LBD) continuum, characterized by neuronal α-synuclein ...

    Stefanie Smolders, Stéphanie Philtjens… in Acta Neuropathologica Communications (2021)

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  3. Article

    Open Access

    Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains

    TAR DNA-binding protein 43 (TDP-43) inclusions are pathological hallmarks of patients with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Loss of TDP-43 in zebrafish engender...

    Jonathan Janssens, Stéphanie Philtjens… in Acta Neuropathologica Communications (2015)

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