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  1. Article

    Open Access

    Fanzor is a eukaryotic programmable RNA-guided endonuclease

    RNA-guided systems, which use complementarity between a guide RNA and target nucleic acid sequences for recognition of genetic elements, have a central role in biological processes in both prokaryotes and euka...

    Makoto Saito, Peiyu Xu, Guilhem Faure, Samantha Maguire, Soumya Kannan… in Nature (2023)

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  2. Article

    Open Access

    Cryo-EM structure of the transposon-associated TnpB enzyme

    The class 2 type V CRISPR effector Cas12 is thought to have evolved from the IS200/IS605 superfamily of transposon-associated TnpB proteins1. Recent studies have identified TnpB proteins as miniature RNA-guided D...

    Ryoya Nakagawa, Hisato Hirano, Satoshi N. Omura, Suchita Nety, Soumya Kannan… in Nature (2023)

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  3. Article

    Open Access

    Structure of the IscB–ωRNA ribonucleoprotein complex, the likely ancestor of CRISPR-Cas9

    Transposon-encoded IscB family proteins are RNA-guided nucleases in the OMEGA (obligate mobile element-guided activity) system, and likely ancestors of the RNA-guided nuclease Cas9 in the type II CRISPR-Cas ad...

    Kazuki Kato, Sae Okazaki, Soumya Kannan, Han Altae-Tran… in Nature Communications (2022)

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  4. Article

    Open Access

    Structure of the OMEGA nickase IsrB in complex with ωRNA and target DNA

    RNA-guided systems, such as CRISPR–Cas, combine programmable substrate recognition with enzymatic function, a combination that has been used advantageously to develop powerful molecular technologies1,2. Structura...

    Seiichi Hirano, Kalli Kappel, Han Altae-Tran, Guilhem Faure, Max E. Wilkinson… in Nature (2022)

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