1 Result(s)

Article

Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forks

The preferential response to PARP inhibitors (PARPis) in BRCA-deficient and Schlafen 11 (SLFN11)-expressing ovarian cancers has been documented, yet the underlying molecular mechanisms remain unclear. As the a...

Hiroshi Onji, Sota Tate, Tomohisa Sakaue, Kohei Fujiwara, Shiho Nakano… in Oncogene (2024)