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  1. Article

    Open Access

    New insights into the biology and development of lung cancer in never smokers—implications for early detection and treatment

    Lung cancer is the leading cause of cancer deaths worldwide. Despite never smokers comprising between 10 and 25% of all cases, lung cancer in never smokers (LCNS) is relatively under characterized from an etio...

    Peiyao Wang, Sophie Sun, Stephen Lam… in Journal of Translational Medicine (2023)

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  2. Article

    Open Access

    Homologous recombination deficiency signatures in gastrointestinal and thoracic cancers correlate with platinum therapy duration

    There is emerging evidence about the predictive role of homologous recombination deficiency (HRD), but this is less defined in gastrointestinal (GI) and thoracic malignancies. We reviewed whole genome (WGS) an...

    Erica S. Tsang, Veronika Csizmok, Laura M. Williamson… in npj Precision Oncology (2023)

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  3. Article

    Early-stage economic analysis of research-based comprehensive genomic sequencing for advanced cancer care

    Genomic research is driving discovery for future population benefit. Limited evidence exists on immediate patient and health system impacts of research participation. This study uses real-world data and quasi-...

    Deirdre Weymann, Janessa Laskin, Steven J. M. Jones… in Journal of Community Genetics (2022)

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  4. No Access

    Article

    Barriers and Facilitators to Participation in Health Screening: an Umbrella Review Across Conditions

    Screening is an essential prevention practice for a number of health conditions. However, screening coverage remains generally low. Studies that investigate determinants of screening participation are becoming...

    Alice Le Bonniec, Sophie Sun, Amandine Andrin, Alexandra L. Dima… in Prevention Science (2022)

  5. No Access

    Article

    Patient ethnicity and cascade genetic testing: a descriptive study of a publicly funded hereditary cancer program

    Cascade genetic testing for hereditary cancer is highly accurate and cost-effective for identifying individuals at high risk for cancer; however, not all eligible people utilize this service. While sociodemogr...

    Eryn F. Braley, Angela C. Bedard, Jennifer Nuk, Quan Hong… in Familial Cancer (2022)

  6. No Access

    Article

    Breast cancer risk after age 60 among BRCA1 and BRCA2 mutation carriers

    It is not known whether the risk of breast cancer among BRCA1 and BRCA2 mutation carriers after age 60 is high enough to justify intensive screening or prophylactic surgery. Thus, we conducted a prospective analy...

    Neda Stjepanovic, Jan Lubinski, Pal Moller… in Breast Cancer Research and Treatment (2021)

  7. No Access

    Article

    Pan-cancer analysis of advanced patient tumors reveals interactions between therapy and genomic landscapes

    Advanced and metastatic tumors with complex treatment histories drive cancer mortality. Here we describe the POG570 cohort, a comprehensive whole-genome, transcriptome and clinical dataset, amenable for explor...

    Erin Pleasance, Emma Titmuss, Laura Williamson, Harwood Kwan, Luka Culibrk… in Nature Cancer (2020)

  8. No Access

    Article

    Balancing uncertainty with patient autonomy in precision medicine

    By the nature of their unknown pathogenicity, variants of unknown significance (VUS) should not inform clinical decisions for genetic carrier testing; nevertheless, VUS are increasingly returned to patients. W...

    Samantha Pollard, Sophie Sun, Dean A. Regier in Nature Reviews Genetics (2019)

  9. No Access

    Article

    Willingness of breast cancer patients to undergo biopsy and breast cancer clinicians’ practices around seeking biopsy at the time of breast cancer relapse

    The practice of seeking a biopsy to confirm a metastatic relapse of a prior breast cancer is individualized. Tumor samples have well-recognized importance in clinical and translational research, but also an in...

    Caroline Lohrisch, Mia Francl, Sophie Sun… in Breast Cancer Research and Treatment (2018)

  10. No Access

    Article

    Electronic and resonance effects on the lonization of structural analogues of efavirenz

    The solubility of 4 analogues of efavirenz was studied as a function of pH. The study evaluated the ionization behavior and determined the relative contribution of electronegative substituents versus resonance...

    Shelley R. Rabel, Sophie Sun, Michael B. Maurin, Mona Patel in AAPS PharmSci (2015)

  11. No Access

    Chapter

    The Future of Lung Cancer

    Current treatments for lung cancer have limited effectiveness and unfortunately, therefore, prognosis remains poor. Major insights into the molecular pathogenesis of lung cancers have led to new and exciting a...

    Sophie Sun, Joan H. Schiller, Monica Spinola, John D. Minna in Lung Cancer (2010)

  12. No Access

    Article

    Lung cancer in never smokers — a different disease

  13. About 25% of lung cancer cases worldwide are not attributable to tobacco smoking. Thus, lung cancer in never smokers is the seventh leading cause of cancer dea...

    14. Sophie Sun, Joan H. Schiller, Adi F. Gazdar in Nature Reviews Cancer (2007)

  14. No Access

    Article

    Androgen receptor and familial prostate cancer

    Sophie Sun, Steven A. Narod, Arman Aprikian, Parviz Ghadirian… in Nature Medicine (1995)