-
Article
Characteristics and risk factors of axillary lymph node metastasis of microinvasive breast cancer
To select patients who would benefit most from sentinel lymph node biopsy (SLNB) by investigating the characteristics and risk factors of axillary lymph node metastasis (ALNM) in microinvasive breast cancer (M...
-
Article
Open AccessRUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts
Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled border. However, the molecular mechanisms underlying lysosomal trafficking and secretion in o...
-
Article
Open Access5-aminosalicylic acid suppresses osteoarthritis through the OSCAR-PPARγ axis
Osteoarthritis (OA) is a progressive and irreversible degenerative joint disease that is characterized by cartilage destruction, osteophyte formation, subchondral bone remodeling, and synovitis. Despite affect...
-
Article
Open AccessIgSF11 deficiency alleviates osteoarthritis in mice by suppressing early subchondral bone changes
Osteoarthritis (OA) is a degenerative joint disease. While it is classically characterized by articular cartilage destruction, OA affects all tissues in the joints and is thus also accompanied by local inflamm...
-
Article
Open AccessDysbiosis of gut microbiota during fecal stream diversion in patients with colorectal cancer
The effect of fecal stream diversion on the gut microbiota is still uncertain. The present study was designed to assess the effect of fecal stream diversion on the composition of the gut microbiota in patients...
-
Article
A Physics-informed and data-driven deep learning approach for wave propagation and its scattering characteristics
Understanding the propagation of waves and their scattering characteristics is critical in various scientific and engineering domains. While the majority of present work is based on numerical approaches, their...
-
Article
Clinical significance of microinvasive breast cancer across the different subtypes and human epidermal growth factor receptor 2 expression levels
The clinical behavior, prognosis, and management of microinvasive breast cancer (MiBC) is controversial. We aimed to clarify its significance across different subtypes and the role of human epidermal growth fa...
-
Article
Open AccessWafer map failure pattern classification using geometric transformation-invariant convolutional neural network
Wafer map defect pattern classification is essential in semiconductor manufacturing processes for increasing production yield and quality by providing key root-cause information. However, manual diagnosis by f...
-
Article
Open AccessImpact of non-muscle cutting periumbilical transverse incision on the risk of incisional hernia as compared to midline incision during laparoscopic colon cancer surgery: a study protocol for a multi-centre randomised controlled trial
Minimally invasive surgery has become popular as a surgical approach for colorectal cancer because it has fewer complications related to the abdominal incision and perioperative complications. However, the inc...
-
Article
Open AccessPredicting multipotency of human adult stem cells derived from various donors through deep learning
Adult stem cell-based therapeutic approaches have great potential in regenerative medicine because of their immunoregulatory properties and multidifferentiation capacity. Nevertheless, the outcomes of stem cel...
-
Article
Open AccessPim1 promotes IFN-β production by interacting with IRF3
The Pim (proviral integration site for Moloney murine leukemia virus) proteins compose a serine threonine kinase family whose members regulate cell proliferation, migration and cell survival. However, whether ...
-
Article
Open AccessA Systematic Map** Study and Empirical Comparison of Data-Driven Intrusion Detection Techniques in Industrial Control Networks
A rising communication between modern industrial control infrastructure and the external Internet worldwide has led to a critical need to secure the network from multifarious cyberattacks. An intrusion detecti...
-
Article
Open AccessAnastomotic leak after minimally invasive anterior resection for rectal cancer with high versus low ligation of the inferior mesenteric artery: a study protocol for a multicentre randomized clinical trial
Although many efforts have been made to decrease the incidence of anastomotic leak (AL), it remains one of the most serious complications of rectal cancer surgery. Many previous studies have reported an associ...
-
Article
Open AccessAdvances of LINAC-based boron neutron capture therapy in Korea
Boron neutron capture therapy (BNCT) has been attracting interest as a new radiation modality for cancer therapy because it can selectively destroy cancer cells while maintaining the healthy state of surroundi...
-
Article
Open AccessBCAT1 promotes osteoclast maturation by regulating branched-chain amino acid metabolism
Branched-chain aminotransferase 1 (BCAT1) transfers the amine group on branched-chain amino acids (BCAAs) to alpha-ketoglutarate. This generates glutamate along with alpha-keto acids that are eventually oxidiz...
-
Article
Periumbilical Transverse Incision for Reducing Incisional Hernia in Laparoscopic Colon Cancer Surgery
Although off-midline incisions (unilateral low transverse or Pfannenstiel incision) have been reported to have a lower incidence of incisional hernia (IH) than periumbilical vertical incision for the purpose o...
-
Article
Open AccessCatch-up growth of infants born to mothers with autoimmune rheumatic disorders
In women with autoimmune rheumatic disorders (ARD), pregnancy complications or postpartum events are more frequent compared to the general population. Transplacental autoantibodies or cytokines influence vario...
-
Article
Febrile infants: written guidelines to reduce non-essential hospitalizations
-
Article
Perineural invasion and number of retrieved lymph nodes are prognostic factors for T2N0 colon cancer
The prognosis of pathological T2N0 colon cancer has not been adequately investigated. This study aimed to determine the prognostic factors for pathological T2N0 colon cancer by comparing it with those for path...
-
Article
Open AccessSelenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts
Selenoproteins containing selenium in the form of selenocysteine are critical for bone remodeling. However, their underlying mechanism of action is not fully understood. Herein, we report the identification of...
