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Article
Tricaprin as a membrane permeability regulator: sustained small hydrophilic substance release from liposomes
Incorporating fatty acids into the phospholipid bilayer affects membrane packing order and permeability. We recently demonstrated that incorporating triglyceride into liposomes may alter membrane packing order...
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Article
Open AccessNanocomposites-based targeted oral drug delivery systems with infliximab in a murine colitis model
Infliximab (IFX), a TNF-α blocking chimeric monoclonal antibody, induces clinical response and mucosal healing in patients with inflammatory bowel disease (IBD). However, systemic administration of this agent ...
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Article
Open AccessTernary nanocomposite carriers based on organic clay-lipid vesicles as an effective colon-targeted drug delivery system: preparation and in vitro/in vivo characterization
This study aimed to develop a new colon-targeted drug delivery system via the preparation of ternary nanocomposite carriers based on organic polymer, aminoclay and lipid vesicles. Budesonide (Bud), an anti-inf...
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Article
Hymenobacter segetis sp. nov., isolated from soil
A polyphasic taxonomic study was performed on a novel strain designated as S7-3-11T, which was isolated from soil of the Gyeongsangnam-do province in Republic of Korea. Phylogenetic analysis based on 16S rRNA gen...
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Article
Comparison of the adjuvanticity of two adjuvant formulations containing de-O-acylated lipooligosaccharide on Japanese encephalitis vaccine in mice
Adjuvants are essential vaccine components used to enhance, accelerate, and/or prolong adaptive immunity against specific vaccine antigens. In this study, we compared the adjuvanticity of two adjuvant formulat...
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Article
Discovery of LW6 as a new potent inhibitor of breast cancer resistance protein
The present study aimed to discover a new potent BCRP inhibitor overcoming multidrug resistance.
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Article
High performance liquid chromatographic determination of YJC-10592, a new chemokine receptor 2 (CCR-2) antagonist, in biological samples
YJC-10592, a new chemokine receptor 2 (CCR-2) antagonist, was newly synthesized for the treatment of asthma and atopic dermatitis. To evaluate the pharmacokinetic characteristics of YJC-10592, a high-performan...
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Article
Current advances in develo** cationic lipid-based nanoparticles as a vehicle for improving adenoviral gene delivery
Preclinical and early clinical studies of the adenovirus-based vectors for gene therapy have shown considerable promise for the future. Use of adenoviral vectors in gene therapy is, however, limited by the lac...
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Article
Pharmacokinetics of YJC-10592, a novel chemokine receptor 2 (CCR-2) antagonist, in rats
YJC-10592, a novel chemokine receptor 2 (CCR-2) antagonist, was developed for treating asthma and atopic dermatitis. We studied the pharmacokinetic characteristics of YJC-10592 after intravenous (5, 10 and 20 ...
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Article
Long chain microRNA conjugates in calcium phosphate nanoparticles for efficient formulation and delivery
A long chain microRNA-34a conjugate (lc-miRNA) was prepared by chemical crosslinking in order to improve entrapment efficiency into calcium phosphate nanoparticles (CaPs) and intracellular delivery. Thiol-modi...
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Article
Laboratory scale production of injectable liposomes by using cell disruptor to avoid the probe sonication process
Multilamellar vesicle (MLV)-type liposomes are promising carriers for hydrophobic drugs that need to be injected. In MLV preparation process, probe sonication step is often required to obtain liposomes fulfill...
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Article
Vitamin D in cancer: effects of pharmaceutical drugs on the vitamin D pharmacokinetics
Vitamin D is a fat-soluble vitamin and has reported anti-cancer and anti-inflammatory properties as well as bone homeostasis through the modulation of gene transcription and non-genomic signaling cascades. The...
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Article
Computed Tomography-Guided Screening of Surfactant Effect on Blood Circulation Time of Emulsions: Application to the Design of an Emulsion Formulation for Paclitaxel
In an effort to apply the imaging techniques currently used in disease diagnosis for monitoring the pharmacokinetics and biodisposition of particulate drug carriers, we sought to use computed tomography (CT) s...
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Article
Cyclooxygenase-2/prostaglandin E2 inducing Effects of α-tocopheryl polyethylene glycol succinate in lung epithelial cells
Tocopherol analogs are known to have pleiotropic effects due to its interaction with diverse intracellular targets. Previously we reported that low/subapoptotic dose of α-tocopheryl succinate (αTOS) inhibits c...
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Article
Nanoscale iodized oil emulsion: a useful tracer for pretreatment sentinel node detection using CT lymphography in a normal canine gastric model
Pretreatment identification of the sentinel lymph nodes (SLNs) in gastric cancer patients may have great advantages for minimally invasive treatment. No reliable method for the detection of SLNs during the pre...
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Article
Tributyrin emulsion as a potent inhibitor of serum- or heregulin-stimulated proliferation of colon cancer cells
Blockade of the heregulin-mediated growth signaling is important to prevent the proliferation of colon cancer. We previously reported that butyrate is a potent inhibitor of the heregulin-stimulated proliferati...
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Article
Wound healing evaluation of sodium fucidate-loaded polyvinylalcohol/sodium carboxymethylcellulose-based wound dressing
The cross-linked hydrogel films containing sodium fucidate were previously reported to be prepared polyvinyl alcohol (PVA) and sodium carboxymethylcellulose (Na-CMC) using the freeze-thawing method and their p...
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Article
Liposomes Coloaded with Iopamidol/Lipiodol as a RES-Targeted Contrast Agent for Computed Tomography Imaging
The need for computed tomography (CT) of reticuloendothelial system (RES)-rich organs such as the liver is increasing, particularly in patients with suspected hepatic metastasis. CT images of the liver have be...
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Article
Effect of sodium carboxymethylcellulose and fucidic acid on the gel characterization of polyvinylalcohol-based wound dressing
The purpose of this study was to investigate the effect of sodium carboxymethylcellulose (Na-CMC) and fucidic acid on the gel characterization for the development of sodium fucidate-loaded wound dressing. The ...
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Article
Open Accessα-Tocopheryl succinate potentiates the paclitaxel-induced apoptosis through enforced caspase 8 activation in human H460 lung cancer cells
Paclitaxel is one of the chemotheraputic drugs widely used for the treatment of nonsmall cell lung cancer (NSCLC) patients. Here, we tested the ability of α-tocopheryl succinate (TOS), another promising antica...
