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Article
Open AccessEvaluation of antioxidant activity and fermentation properties of potential probiotic strain Lactiplantibacillus plantarum HY7720 in plant-based materials
People on vegan diets are at risk of being deficient in varied nutrients such as vitamin B12 and certain amino acids. In this study, we investigated vitamin B12-producing lactic acid bacteria (LAB) as well as the...
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Article
Hyaluronan suppresses lidocaine-induced apoptosis of human chondrocytes in vitro by inhibiting the p53-dependent mitochondrial apoptotic pathway
Intra-articular injection of local anesthetics (LAs) is a common procedure for therapeutic purposes. However, LAs have been found toxic to articular cartilage, and hyaluronan may attenuate this toxicity. In th...
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Article
Antimicrobial effect of photodynamic therapy using a highly pure chlorin e6
The aim of the present study is to evaluate the antimicrobial effect of photodynamic therapy (PDT) using a highly pure chlorin e6 (Ce6), against various pathogenic bacteria. To examine the antimicrobial effect of...
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Article
Open AccessEpigallocatechin-3-gallate suppresses the expression of HSP70 and HSP90 and exhibits anti-tumor activity in vitro and in vivo
Epigallocatechin-3-gallate (EGCG), one of the major catechins in green tea, is a potential chemopreventive agent for various cancers. The aim of this study was to examine the effect of EGCG on the expression o...
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Article
Open AccessInhibition of trichostatin A-induced antiangiogenesis by small-interfering RNA for thrombospondin-1
Expression of thrombospondin-1 (TSP-1), which is a known inhibitor of tumor growth and angiogenesis, is reciprocally regulated by positive regulators, such as VEGF. Additionally, trichostatin A (TSA) suppresse...
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Article
Open AccessWeakening of the repressive YY-1 site on the thrombospondin-1 promoter via c-Jun/YY-1 interaction
Thrombospondin-1 (TSP-1) level is tightly regulated at the transcriptional level. To determine the detailed molecular mechanisms of TSP-1 expression, nine serial 5'-deletion constructs of the human genomic tsp...
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Article
Open AccessCell-type specific regulation of thrombospondin-1 expression and its promoter activity by regulatory agents
Thrombospondin-1 (TSP-1), a multifunctional protein that is able to function as a negative regulator of solid tumor progression and angiogenesis, is normally present at a very low level but rapidly elevated in...
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Article
Expression of thrombospondin-1 in human hepatocarcinoma cell lines and its regulation by transcription factor Jun/AP-1
Thrombospondin-1 (TSP-1) is a homotrimeric glycoprotein synthesized in a variety of normal and transformed cells, and secreted into the extracellular matrix. Based on its known effects on the tumor and endothe...
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Article
Open AccessResponsive site on the thrombospondin-1 promotor to down-regulation by phorbol 12-myristate 13-acetate in porcine aortic endothelial cells
Thrombospondin-1 (TSP-1), a multifunctional extracellular matrix protein, inhibits neovascularization and is implicated in the regression of tumor growth and metastasis. We found that the synthesis of TSP-1 in...
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Article
Open AccessInhibition of apo(a) synthesis by several cell-growth regulating agents in two human hepatocarcinoma cell lines, SK-HEP-1 and Hep 3B cells
The effects of cell-growth regulating agents of apolipoprotein(a) [apo(a)] synthesis were examined in human hepatocarcinoma cell lines. Among four cell lines, apo(a) can be detected in three cell lines, SK-HEP...
