-
Article
Open AccessMycobacterium abscessus pathogenesis identified by phenogenomic analyses
The medical and scientific response to emerging and established pathogens is often severely hampered by ignorance of the genetic determinants of virulence, drug resistance and clinical outcomes that could be u...
-
Article
Open AccessAssessment of protein–protein interfaces in cryo-EM derived assemblies
Structures of macromolecular assemblies derived from cryo-EM maps often contain errors that become more abundant with decreasing resolution. Despite efforts in the cryo-EM community to develop metrics for map ...
-
Article
Open AccessIdentification and Characterization of Genetic Determinants of Isoniazid and Rifampicin Resistance in Mycobacterium tuberculosis in Southern India
Drug-resistant tuberculosis (TB), one of the leading causes of death worldwide, arises mainly from spontaneous mutations in the genome of Mycobacterium tuberculosis. There is an urgent need to understand the mech...
-
Article
Open AccessPublisher Correction: Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
-
Article
Open AccessStructural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae
The rpoB gene encodes the β subunit of RNA polymerase holoenzyme in Mycobacterium leprae (M. leprae). Missense mutations in the rpoB gene were identified as etiological factors for rifampin resistance in leprosy....
-
Article
Open AccessGenome sequencing of herb Tulsi (Ocimum tenuiflorum) unravels key genes behind its strong medicinal properties
Krishna Tulsi, a member of Lamiaceae family, is a herb well known for its spiritual, religious and medicinal importance in India. The common name of this plant is ‘Tulsi’ (or ‘Tulasi’ or ‘Thulasi’) and is cons...
-
Article
Open AccessDOCKSCORE: a webserver for ranking protein-protein docked poses
Proteins interact with a variety of other molecules such as nucleic acids, small molecules and other proteins inside the cell. Structure-determination of protein-protein complexes is challenging due to several...
-
Article
Open AccessSequence search and analysis of gene products containing RNA recognition motifs in the human genome
Gene expression is tightly regulated at both transcriptional and post-transcriptional levels. RNA-binding proteins are involved in post-transcriptional gene regulation events. They are involved in a variety of...
-
Article
Open AccessRe-visiting protein-centric two-tier classification of existing DNA-protein complexes
Precise DNA-protein interactions play most important and vital role in maintaining the normal physiological functioning of the cell, as it controls many high fidelity cellular processes. Detailed study of the ...
