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Article
Open AccessFission yeast Cdc14-like phosphatase Flp1/Clp1 modulates the transcriptional response to oxidative stress
Reactive oxygen species (ROS) are an important source of cellular damage. When ROS intracellular levels increase, oxidative stress takes place affecting DNA stability and metabolic functions. To prevent these ...
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Article
Open AccessFunctional crosstalk between the cohesin loader and chromatin remodelers
The cohesin complex participates in many structural and functional aspects of genome organization. Cohesin recruitment onto chromosomes requires nucleosome-free DNA and the Scc2-Scc4 cohesin loader complex tha...
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Article
Open AccessConserved roles of chromatin remodellers in cohesin loading onto chromatin
Cohesin is a conserved, ring-shaped protein complex that topologically entraps DNA. This ability makes this member of the structural maintenance of chromosomes (SMC) complex family a central hub of chromosome ...
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Article
Open AccessStructure of the cohesin loader Scc2
The functions of cohesin are central to genome integrity, chromosome organization and transcription regulation through its prevention of premature sister-chromatid separation and the formation of DNA loops. Th...
