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Article
Inhibition of histone deacetylase activity increases chromosomal instability by the aberrant regulation of mitotic checkpoint activation
Histone modification through acetylation and deacetylation is a key process in transcription, DNA replication, and chromosome segregation. During mitosis, histones are highly acetylated and chromatin is conden...
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Article
Open AccessAcupuncture for persistent allergic rhinitis: a multi-centre, randomised, controlled trial protocol
Allergic rhinitis is one of the most common health complaints worldwide. Complementary and alternative medical approaches have been employed to relieve allergic rhinitis symptoms and to avoid the side effects ...
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Article
Open AccessAlcohol consumption and carotid artery structure in Korean adults aged 50 years and older
Epidemiologic studies of the association between alcohol consumption and carotid artery structure have reported conflicting results. We investigated the association between alcohol consumption and carotid athe...
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Article
Open AccessAcupuncture for dry eye: a randomised controlled trial protocol
Dry eye is usually managed by conventional medical interventions such as artificial tears, anti-inflammatory drugs and surgical treatment. However, since dry eye is one of the most frequent ophthalmologic diso...
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Open AccessAcupuncture for dry eye: a multicentre randomised controlled trial with active comparison intervention (artificial tear drop) using a mixed method approach protocol
Previous studies of acupuncture show favourable results for both subjective and objective outcomes of dry eye. However, firm conclusions could not be drawn from these studies because the quality of the trials ...
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Article
Open AccessCumulative smoking exposure, duration of smoking cessation, and peripheral arterial disease in middle-aged and older Korean men
We investigated the association of cumulative smoking exposure and duration of smoking cessation with peripheral arterial disease (PAD).
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Article
Open AccessEvaluation of wet-cup** therapy for persistent non-specific low back pain: a randomised, waiting-list controlled, open-label, parallel-group pilot trial
Persistent non-specific low back pain (PNSLBP) is one of the most frequently experienced types of back pain around the world. Wet-cup** is a common intervention for various pain conditions, especially in Kor...
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Article
Open AccessAssociation of smoking status, cumulative smoking, duration of smoking cessation, age of starting smoking, and depression in Korean adults
Many previous studies did not sufficiently control for several confounding factors that may affect the association between smoking and depression, such as socioeconomic status. We investigated the association ...
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Article
Open AccessEfficacy of moxibustion for pre- or stage I hypertension: study protocol for a pilot randomized controlled trial
Hypertension is a risk factor for cardiovascular disease, and the prevalence of hypertension tends to increase with age. Current treatments for hypertension have adverse side effects and poor adherence. The pu...
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Article
Open AccessAn open-label study of effects of acupuncture on chronic fatigue syndrome and idiopathic chronic fatigue: study protocol for a randomized controlled trial
Even though chronic fatigue syndrome and idiopathic chronic fatigue are quite common, there are no clearly known causes. Most treatments are therefore symptomatic in nature, and chronic fatigue syndrome and id...
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Article
Open AccessElectroacupuncture to treat painful diabetic neuropathy: study protocol for a three-armed, randomized, controlled pilot trial
The purpose of this study is to conduct a basic analysis of the effectiveness and safety of electroacupuncture in the treatment of painful diabetic neuropathy (PDN) as compared to placebo and usual care and to...
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Article
Open AccessElectroacupuncture for chemotherapy-induced peripheral neuropathy: study protocol for a pilot multicentre randomized, patient-assessor-blinded, controlled trial
Chemotherapy-induced peripheral neuropathy (CIPN) is the main dose-limiting side effect of neurotoxic chemotherapeutic agents. CIPN can lead not only to loss of physical function, difficulties in activities of...
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Article
Open AccessAuricular acupuncture for prehypertension and stage 1 hypertension: study protocol for a pilot multicentre randomised controlled trial
Hypertension, a worldwide public health problem, is a major risk factor for cardiovascular and kidney disease, and the medical and economic burden of hypertension is increasing. Auricular acupuncture has been ...
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Article
Open AccessHousehold and area income levels are associated with smoking status in the Korean adult population
Some previous studies have suggested that area-level characteristics have effects on smoking. The aim of this study was to evaluate the associations between household income and area income on smoking in Korea...
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Article
Effects of Oxytocin on Neural Response to Facial Expressions in Patients with Schizophrenia
Impaired facial emotion recognition is a core deficit in schizophrenia. Oxytocin has been shown to improve social perception in patients with schizophrenia; however, the effect of oxytocin on the neural activi...
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Article
Open AccessAcupuncture for chronic fatigue syndrome and idiopathic chronic fatigue: a multicenter, nonblinded, randomized controlled trial
The causes of chronic fatigue syndrome (CFS) and idiopathic chronic fatigue (ICF) are not clearly known, and there are no definitive treatments for them. Therefore, patients with CFS and ICF are interested in ...
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Article
Erratum: Effects of Oxytocin on Neural Response to Facial Expressions in Patients with Schizophrenia
Correction to: Neuropsychopharmacology advance online publication 4 March 2015; doi:10.1038/npp.2015.41 In this article, the correct affiliation for So-Yeon Kim is Department of Psychology, Duksung Women’s Uni...
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Open AccessA multi-center, randomized controlled clinical trial, cost-effectiveness and qualitative research of electroacupuncture with usual care for patients with non-acute pain after back surgery: study protocol for a randomized controlled trial
Although pain after back surgery is known to be difficult to control, various treatment options are available to patients and physicians. A protocol for a confirmatory randomized controlled trial (RCT) on pain...
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Article
Open AccessThe efficacy and safety of the herbal medicine geonchildan for patients with active rheumatoid arthritis: study protocol for a randomized, double-blind, placebo-controlled, parallel pilot trial
This study aims to assess the efficacy and safety of geonchildan, a Korean traditional herbal medicine, for patients with active rheumatoid arthritis (RA) and evaluate the feasibility of a large-scale confirmator...
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Article
Open AccessVisit-to-visit systolic blood pressure variability in patients with ST-elevation myocardial infarction predicts long-term cardiovascular outcomes
Elevated visit-to-visit blood pressure variability (BPV), independent of mean BP, has been associated with cardiovascular events. However, its impact after ST-elevation myocardial infarction (STEMI) has not be...