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Article
Association of Cough Severity with Asthma Control and Quality of Life in Patients with Severe Asthma
Symptoms are important components in determining asthma control and in the adjustment of treatment levels. However, clinical relevance of cough in severe asthma is not well-understood. This study aimed to eval...
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Article
Regulatory Framework for Drug-Device Combination Products in the United States, Europe, and Korea
Combination products (CPs) combine two or more product types such as drugs, devices, and/or biological products for increased safety and clinical effectiveness. The emergence of innovative CPs poses new challe...
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Article
Predictors of Early and Late Lung Function Improvement in Severe Eosinophilic Asthma on Type2-Biologics in the PRISM Study
The determinants linked to the short- and long-term improvement in lung function in patients with severe eosinophilic asthma (SEA) on biological treatment (BioT) remain elusive.
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Article
Association between SYVN1 and SEL1 genetic polymorphisms and remission in rheumatoid arthritis patients treated with TNF-α inhibitors: a machine learning approach
Rheumatoid arthritis (RA) is a severe chronic inflammatory condition that affects joint synovium. Suppressor/enhancer of lin-12-like (SEL1L)–Synoviolin 1 (SYVN1)-mediated endoplasmic reticulum–associated degra...
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Article
Open AccessA higher probability of subsequent stroke and ischemic heart disease in migraine patients: a longitudinal follow-up study in Korea
Whether migraine is related to the risk of cardiovascular diseases (CVDs) remains unclear. Therefore, we conducted a longitudinal follow-up study to address the association between migraine and the development...
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Article
Open AccessLongitudinal study of the inverse relationship between Parkinson’s disease and cancer in Korea
Despite growing epidemiological evidence, the relationship between Parkinson’s disease (PD) and cancer has not been conclusively demonstrated, and related studies are scarce in the Asian population. We aimed t...
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Article
Open AccessChanges in the mean incidence and variance of orthopedic diseases before and during the COVID-19 pandemic in Korea: a retrospective study
During the coronavirus disease (COVID-19) pandemic, the amount of moderate- to high-intensity physical activity significantly decreased. Therefore, the epidemiology of musculoskeletal diseases could possibly h...
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Article
Open AccessLongitudinal follow-up study of the association with gout and Alzheimer’s disease and Parkinson’s disease in Korea
To date, no clear conclusion on the relationships of gout with the occurrence of typical neurodegenerative diseases, Alzheimer’s disease (AD) and Parkinson’s disease (PD), has been reached. This study aimed to...
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Living Reference Work Entry In depth
Reducing the Generational Transmission of Poverty Through Promotion of Health Behaviors: “Juntos” Social Marketing Program in Peru
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Article
Association between metabolic syndrome and osteoporosis among adults aged 50 years and older: using the National Health Information Database in South Korea
This study aimed to examine the association between a history of metabolic syndrome (MetS) and osteoporosis with specific characteristics. The results showed that MetS was inversely associated with osteoporosi...
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Article
Diagnosing ulnar neuropathy at the elbow on MRI: importance of the longitudinal extent of the hyperintense ulnar nerve
To evaluate the usefulness of the longitudinal extent (LE) of high ulnar nerve signal intensity (SI) for the diagnosis of ulnar neuropathy at the elbow (UNE).
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Article
Open AccessAssociations between proton pump inhibitors and Alzheimer’s disease: a nested case–control study using a Korean nationwide health screening cohort
Safety concerns against the use of proton pump inhibitors (PPIs) based on the risk of dementia, especially Alzheimer’s disease (AD), remain controversial. Here, we investigated the likelihood of AD depending o...
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Article
Open AccessLongitudinal follow-up study of the association between statin use and chronic periodontitis using national health screening cohort of Korean population
Since a potential link between statins and the risk of adverse chronic periodontitis (CP) has been raised, we aimed to validate the association between statin use and the incidence of CP using nationwide cohor...
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Article
Open AccessElectroacupuncture for treating cancer-related insomnia: a multicenter, assessor-blinded, randomized controlled, pilot clinical trial
Insomnia is one of the most frequent symptoms in people with cancer. Electroacupuncture has been widely used in people with cancer or insomnia. We explored the feasibility and preliminary effectiveness of elec...
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Article
Open AccessThe associations of previous influenza/upper respiratory infection with COVID-19 susceptibility/morbidity/mortality: a nationwide cohort study in South Korea
We aimed to investigate the associations of previous influenza/URI with the susceptibility of COVID-19 patients compared to that of non-COVID-19 participants. A nationwide COVID-19 cohort database was collecte...
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Article
Corona enhancement can substitute enhancing capsule in the imaging diagnosis of small (≤ 3 cm) HCCs on gadoxetic acid–enhanced MRI
This study aimed to elucidate the relationship between gadoxetic acid–enhanced magnetic resonance imaging (MRI) features—enhancing capsule, corona enhancement or hypointense rim—observed in hepatocellular carc...
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Article
Open AccessAssociation of TLR 9 gene polymorphisms with remission in patients with rheumatoid arthritis receiving TNF-α inhibitors and development of machine learning models
Toll-like receptor (TLR)-4 and TLR9 are known to play important roles in the immune system, and several studies have shown their association with the development of rheumatoid arthritis (RA) and regulation of ...
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Article
Sclerotic changes of cavernous hemangioma in the cirrhotic liver: long-term follow-up using dynamic contrast-enhanced computed tomography
To determine the intra- and extralesional factors that predict sclerotic degeneration of hepatic hemangiomas in the cirrhotic liver on long-term follow-up computed tomography (CT) examinations.
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Article
Open AccessCollateral effects of the coronavirus disease 2019 pandemic on lung cancer diagnosis in Korea
The COVID-19 pandemic is predicted to significantly affect patients with lung cancer, owing to its rapid progression and high mortality. Studies on lung cancer diagnosis and treatment during an epidemic are la...
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Article
Development of a Gd2O2S:Tb Phosphor Screen with an Anti-reflective Layer Fabricated Using Poly Chloro-para-xylylene to Improve Optical Properties in Radiography
In this study, we developed a Gd2O2S:Tb screen with a parylene-C-based antireflective (AR) layer and evaluated its optical and X-ray response properties; in particular, we focused on develo** an AR coating laye...
