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  1. No Access

    Article

    Molecular hybridization method for obtaining paeonol-based fibrate derivatives with potent lipid-lowering and hepatoprotective activity

    Molecular hybridization method was applied to design and synthesize a series of target compounds paeonol-based fibrate derivatives. The target compound was screened using a Triton WR-1339 induced hyperlipidemi...

    Lina Quan, Ying Guo, Siyao Wang, Mengfei Sun, Yan Pang… in Medicinal Chemistry Research (2024)

  2. No Access

    Article

    Sexual dimorphism in thermogenic regulators and metrnl expression in adipose tissue of offspring mice exposed to maternal and postnatal overnutrition

    Current study investigated the impact of maternal and postnatal overnutrition on phenotype of adipose, in relation to offspring thermogenesis and sex. Female C57BL/6 J mice were fed with CHOW or high fat diet ...

    Zhao Yang, Jianan Jiang, Yutian Tan, Guiying Yang… in Journal of Physiology and Biochemistry (2024)

  3. No Access

    Article

    Structural simplification and ester bond flip** lead to bis-benzodioxole derivatives as potential hypolipidemic and hepatoprotective agent

    A series of bis-benzodioxole derivatives was designed, synthesized, and evaluated. These target compounds were designed through structure simplification and ester bond flip**. The lipid-lowering activity of ...

    Yundong **e, Siyao Wang, Mengfei Sun, Yan Pang, Ji** Liu… in Medicinal Chemistry Research (2024)