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Open AccessRelationship between serum apolipoprotein B and risk of all-cause and cardiovascular disease mortality in individuals with hypertension: a prospective cohort study
Dyslipidemia frequently coexists with hypertension in the population. Apolipoprotein B (ApoB) is increasingly considered a more potent predictor of cardiovascular disease (CVD). Abnormal levels of serum ApoB c...
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Article
Open Access2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis
Sirtuin 3 (SIRT3) is well known as a conserved nicotinamide adenine dinucleotide+ (NAD+)-dependent deacetylase located in the mitochondria that may regulate oxidative stress, catabolism and ATP production. Accumu...
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Article
Open AccessIncreased susceptibility to new-onset atrial fibrillation in diabetic women with poor sleep behaviour traits: findings from the prospective cohort study in the UK Biobank
Diabetic individuals often encounter various sleep-related challenges. Although the association between sleep duration and atrial fibrillation (AF) have been explored, the association of other sleep traits wit...
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Article
Open AccessSuperior predictive value of estimated pulse wave velocity for all-cause and cardiovascular disease mortality risk in U.S. general adults
Estimated pulse wave velocity (ePWV) has been proposed as a potential approach to estimate carotid-femoral pulse wave velocity. However, the potential of ePWV in predicting all-cause mortality (ACM) and cardio...
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Article
Open AccessImpact of capitation prepayment on the medical expenses and health service utilization of patients with coronary heart disease: a community policy intervention program in a county in China
Medical costs have been rising rapidly in recent years, and China is controlling medical costs from the perspective of health insurance payments.
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Article
Open AccessImpacting factors and sources of perceived stress by home-quarantined residents in Shanghai during COVID-19 epidemic
Home-quarantine is one of the most common measures implemented to prevent or minimize the transmission of COVID-19 among communities. This study assessed stress levels of the home-quarantined residents in Shan...
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Open AccessComparison of the predictive value of four insulin resistance surrogates for the prevalence of hypertension: a population-based study
Several studies have investigated the association of insulin resistance (IR) surrogates and the risk of hypertension. However, it is unclear whether there exist differences between different IR surrogates and ...
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Article
Open AccessImpact of Increased Hemoglobin on Spontaneous Intracerebral Hemorrhage
Studies of the impact of increased hemoglobin on spontaneous intracerebral hemorrhage (ICH) are limited. The present study aimed to explore the effect of increased hemoglobin on ICH.
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Article
Open AccessCocaine induces paradigm-specific changes to the transcriptome within the ventral tegmental area
During the initial stages of drug use, cocaine-induced neuroadaptations within the ventral tegmental area (VTA) are critical for drug-associated cue learning and drug reinforcement processes. These neuroadapta...
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Article
Open AccessDe novo missense variants disrupting protein–protein interactions affect risk for autism through gene co-expression and protein networks in neuronal cell types
Whole-exome sequencing studies have been useful for identifying genes that, when mutated, affect risk for autism spectrum disorder (ASD). Nonetheless, the association signal primarily arises from de novo prote...
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Open AccessExome sequencing identifies germline variants in DIS3 in familial multiple myeloma