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Article
Open AccessEuropean position paper on polypharmacy and fall-risk-increasing drugs recommendations in the World Guidelines for Falls Prevention and Management: implications and implementation
The recent World Guidelines for Falls Prevention and Management provide several recommendations on how to prevent medication-related falls.
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Article
Open AccessTherapeutic dilemma’s: antipsychotics use for neuropsychiatric symptoms of dementia, delirium and insomnia and risk of falling in older adults, a clinical review
This clinical review summarizes the current evidence on the risks of antipsychotic-related falls in older adults, including aspects of pharmacokinetics and -dynamics to assist clinicians in (de)prescribing ant...
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Article
Open AccessRisk factors of pneumonia in persons with and without Alzheimer’s disease: a matched cohort study
Pneumonia is a very common infection in the cognitively impaired adult population, often leading to long-term deterioration, in physical and cognitive performance. Evidence is lacking on whether chronic comorb...
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Article
Open AccessRecent hospitalization and risk of antidepressant initiation in people with Parkinson’s disease
People with Parkinson’s disease (PD) are more likely to be hospitalized and initiate antidepressant use compared to people without PD. It is not known if hospitalization increases the risk of antidepressant in...
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Article
Open AccessDeprescribing practices, habits and attitudes of geriatricians and geriatricians-in-training across Europe: a large web-based survey
To explore current deprescribing attitudes and practices among geriatricians and geriatricians-in-training across Europe.
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Article
Open AccessStatin discontinuation in persons with and without Alzheimer’s disease
Although statin use is reported to decrease after dementia diagnosis, time to statin discontinuation and factors associated with discontinuation have not been studied in persons with Alzheimer’s disease (AD). ...
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Article
Open AccessPrevalence of oral anticoagulant use among people with and without Alzheimer’s disease
Although cardio- and cerebrovascular diseases are common among people with Alzheimer’s disease (AD), it is unknown how the prevalence of oral anticoagulant (OAC) use changes in relation to AD diagnosis. We inv...
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Article
Open AccessEffect of individually tailored nutritional counselling on protein and energy intake among older people receiving home care at risk of or having malnutrition: a non-randomised intervention study
With ageing, food intake may decrease and lead to an insufficient nutrient intake causing protein-energy malnutrition (PEM) which is associated with adverse health effects and increased mortality. The aim of t...
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Barriers and facilitators in using a Clinical Decision Support System for fall risk management for older people: a European survey
The aim of our study was to assess barriers and facilitators to CDSS use reported by European physicians treating older fallers and explore differences in their perceptions.
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Article
Open AccessAutomated multi-dose dispensing in persons with and without Alzheimer’s disease—impacts on pharmacotherapy
We investigated the drug use before and after transition to automated multi-dose dispensing (MDD) service among persons with Alzheimer’s disease (AD) and compared whether the changes were similar in persons wi...
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Article
Open AccessOpioids and Falls Risk in Older Adults: A Narrative Review
Pain treatment is important in older adults but may result in adverse events such as falls. Opioids are effective for nociceptive pain but the evidence for neuropathic pain is weak. Nevertheless, both pain and...
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Article
Open AccessFactors associated with daily opioid use among aged home care clients: a cross-sectional analysis of Resident Assessment Instrument data
To examine which client characteristics and other factors, including possible adverse effects, identified in the Resident Assessment Instrument-Home Care (RAI-HC) are associated with daily opioid use among age...
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Article
Open AccessChanges in the use of diabetes drugs among community-dwelling people with Alzheimer’s disease
Type 2 diabetes is common in persons with Alzheimer’s disease (AD). Management of diabetes in persons with AD is challenging due to changing goals of care and susceptibility to adverse drug events including hy...
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Article
Open AccessThe prevalence of and exact indications for daily opioid use among aged home care clients with and without dementia
The increasing trend of opioid use for non-malignant pain among older people has raised concerns about whether opioids are used for appropriate indications. On the other hand, pain in patients with dementia ma...
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Open AccessIncidence of antidepressant use among community dwellers with and without Parkinson’s disease – a nationwide cohort study
Antidepressant use is more common in people with Parkinson’s disease (PD), but it is unknown when this difference emerges.
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Open AccessThe effect of comorbidities on survival in persons with Alzheimer’s disease: a matched cohort study
Alzheimer’s disease (AD) is one of the leading causes of death world-wide, but little is known on the role of comorbidities on mortality among people with AD. We studied how comorbidities and age at AD diagnos...
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Article
Open AccessVariation in groundwater manganese in Finland
Increasing evidence has emerged that Mn derived from drinking water could be a health risk, especially for children. This study aimed to provide more information on the variation in Mn concentrations in well w...
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Open AccessCauses of death in a nationwide cohort of community-dwellers with Alzheimer’s disease
Alzheimer’s disease (AD) is related to higher mortality but it is not entirely evident which causes of death explain this. The objective of this study was to assess the causes of death in a nationwide cohort o...
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Article
Application of Healthcare ‘Big Data’ in CNS Drug Research: The Example of the Neurological and mental health Global Epidemiology Network (NeuroGEN)
Neurological and psychiatric (mental health) disorders have a large impact on health burden globally. Cognitive disorders (including dementia) and stroke are leading causes of disability. Mental health disorde...
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Article
Open AccessLength of hospital stay after hip fracture and readmission rates of persons with and without Alzheimer’s disease: a matched cohort study
Hospital length of stays (LOS) for incident of hip fracture are decreasing, but it is unknown if these changes have negative impacts on vulnerable older patient populations, like those with Alzheimer’s disease...
