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Article
Open AccessPioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate
Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles...
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Article
Open AccessIsl2b regulates anterior second heart field development in zebrafish
After initial formation, the heart tube grows by addition of second heart field progenitor cells to its poles. The transcription factor Isl1 is expressed in the entire second heart field in mouse, and Isl1-defici...