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  1. Article

    Open Access

    Cross-reactive CD8+ T cell responses to tumor-associated antigens (TAAs) and homologous microbiota-derived antigens (MoAs)

    We have recently shown extensive sequence and conformational homology between tumor-associated antigens (TAAs) and antigens derived from microorganisms (MoAs). The present study aimed to assess the breadth of ...

    Beatrice Cavalluzzo, Marie Christine Viuff… in Journal of Experimental & Clinical Cancer … (2024)

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  2. No Access

    Article

    Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of myeloid zinc finger-1 serine 27 activates lysosome redistribution and invasion

    HER2/ErbB2 activation turns on transcriptional processes that induce local invasion and lead to systemic metastasis. The early transcriptional changes needed for ErbB2-induced invasion are poorly understood. H...

    Ditte Marie Brix, Siri Amanda Tvingsholm, Malene Bredahl Hansen… in Oncogene (2019)

  3. No Access

    Article

    Molecular and Transcriptional Signatures for ErbB2-Induced Invasion

    Invasion and metastasis are the most fatal activities connected to ErbB2. Current ErbB2-targeting therapies are highly efficient against early stage breast cancer, but often fail to cure the advanced cases. It...

    Siri Amanda Tvingsholm, Ditte Marie Brix, Tuula Kallunki in Current Pharmacology Reports (2019)

  4. Article

    Open Access

    Let-7 microRNA controls invasion-promoting lysosomal changes via the oncogenic transcription factor myeloid zinc finger-1

    Cancer cells utilize lysosomes for invasion and metastasis. Myeloid Zinc Finger1 (MZF1) is an ErbB2-responsive transcription factor that promotes invasion of breast cancer cells via upregulation of lysosomal c...

    Siri Amanda Tvingsholm, Malene Bredahl Hansen… in Oncogenesis (2018)

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