1 Result(s)

Article

Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine

The structure of proline prevents it from adopting an optimal position for rapid protein synthesis. Poly-proline-tract (PPT) associated ribosomal stalling is resolved by highly conserved eIF5A, the only protei...

Víctor Faundes, Martin D. Jennings, Siobhan Crilly, Sarah Legraie… in Nature Communications (2021)