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    Article

    CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection

    Natural hosts of simian immunodeficiency virus (SIV)—such as African green monkeys—have evolved to tolerate SIV infection without develo** immune deficiency. Jason Brenchley and his colleagues provide a mech...

    Coreen M Beaumier, Levelle D Harris, Simoy Goldstein, Nichole R Klatt… in Nature Medicine (2009)

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    Article

    Human CD4+ cells transfected with IL-16 cDNA are resistant to HIV-1 infection: Inhibition of mRNA expression

    Interleukin-16 (IL-16) is secreted by activated CD8+ T lymphocytes and acts on CD4+ T lymphocytes, monocytes and eosinophils. Recently, the C-terminal 130-amino acid portion of IL-16 was shown to suppress HIV-1 r...

    Paul Zhou, Simoy Goldstein, Krishnakumar Devadas, Deepanker Tewari… in Nature Medicine (1997)

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    Chapter

    Host Range Restricted, Non-Replicating Vaccinia Virus Vectors as Vaccine Candidates

    The use of a recombinant virus containing a heterologous gene of another microorganism as a live vaccine was suggested more than 10 years ago (Mackett et al, 1982; Panicali and Paoletti, 1982). Vaccinia virus ...

    Bernard Moss, Miles W. Carroll… in Novel Strategies in the Design and Product… (1996)