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Article
Open AccessHIV- 1 lentivirus tethering to the genome is associated with transcription factor binding sites found in genes that favour virus survival
Lentiviral vectors (LV) are attractive for permanent and effective gene therapy. However, integration into the host genome can cause insertional mutagenesis highlighting the importance of understanding of LV i...
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Article
Open AccessProduction of lentiviral vectors using novel, enzymatically produced, linear DNA
The manufacture of large quantities of high-quality DNA is a major bottleneck in the production of viral vectors for gene therapy. Touchlight Genetics has developed a proprietary abiological technology that ad...
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Article
Fetal gene therapy for neurodegenerative disease of infants
For inherited genetic diseases, fetal gene therapy offers the potential of prophylaxis against early, irreversible and lethal pathological change. To explore this, we studied neuronopathic Gaucher disease (nGD...
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Article
The CD46-Jagged1 interaction is critical for human TH1 immunity
The complement receptor CD46 and the Notch-Jagged system are important for the differentiation of helper T cells. Kemper and colleagues demonstrate that Jagged1 is a physiological ligand for CD46 and is critic...
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Article
Development of S/MAR minicircles for enhanced and persistent transgene expression in the mouse liver
We have previously described the development of a scaffold/matrix attachment region (S/MAR) episomal vector system for in vivo application and demonstrated its utility to sustain transgene expression in the mo...