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Article
Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair
Osteoclasts are multinucleated cells of the monocyte/macrophage lineage that degrade bone. Here, we used lineage tracing studies—labelling cells expressing Cx3cr1, Csf1r or Flt3—to identify the precursors of oste...
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Article
Human centromere repositioning within euchromatin after partial chromosome deletion
Centromeres are defined by a specialized chromatin organization that includes nucleosomes that contain the centromeric histone variant centromere protein A (CENP-A) instead of canonical histone H3. Studies in ...
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Article
Definition and characterization of a region of 1p36.3 consistently deleted in neuroblastoma
Substantial genomic and functional evidence from primary tumors and cell lines indicates that a consistent region of distal chromosome 1p is deleted in a sizable proportion of human neuroblastomas, suggesting ...
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Protocol
Map** Techniques
In 1920, German botanist Hans Winkler first used the term genome, reputedly by the fusion of GENe and chromosOME, in order to describe the complex notion of the entire set of chromosomes and all of the genes cont...
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Article
Organization of the MASP2 locus and its expression profile in mouse and rat
The mouse, rat, and human MASP2 loci are situated on syntenic chromosome regions and are highly conserved. They comprise the genes for MASP-2/MAp19, TAR DNA binding protein of 43 kDa, FRAP kinase, CDT6, Polymyosi...