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  1. Article

    Open Access

    Lentiviral gene therapy rescues p47phox chronic granulomatous disease and the ability to fight Salmonella infection in mice

    Chronic granulomatous disease (CGD) is an inherited primary immunodeficiency disorder characterised by recurrent and often life-threatening infections and hyperinflammation. It is caused by defects of the phag...

    Andrea Schejtman, Walmir Cutrim Aragão-Filho, Simon Clare, Marta Zinicola… in Gene Therapy (2020)

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  2. No Access

    Article

    High-throughput phenoty** reveals expansive genetic and structural underpinnings of immune variation

    By develo** a high-density murine immunophenoty** platform compatible with high-throughput genetic screening, we have established profound contributions of genetics and structure to immune variation ( ...

    Lucie Abeler-Dörner, Adam G. Laing, Anna Lorenc, Dmitry S. Ushakov… in Nature Immunology (2020)

  3. No Access

    Article

    Adaptation of host transmission cycle during Clostridium difficile speciation

    Bacterial speciation is a fundamental evolutionary process characterized by diverging genotypic and phenotypic properties. However, the selective forces that affect genetic adaptations and how they relate to t...

    Nitin Kumar, Hilary P. Browne, Elisa Viciani, Samuel C. Forster… in Nature Genetics (2019)

  4. No Access

    Article

    C13orf31 (FAMIN) is a central regulator of immunometabolic function

    Variants of the human gene C13orf31 (LACC1) are associated with various disease risks. Kaser and colleagues identify a role for the protein encoded (called ‘FAMIN’) in regulating macrophage fatty-acid oxidation a...

    M Zaeem Cader, Katharina Boroviak, Qifeng Zhang, Ghazaleh Assadi… in Nature Immunology (2016)

  5. Article

    Open Access

    Probing local innate immune responses after mucosal immunisation

    Intranasal immunisation is potentially a very effective route for inducing both mucosal and systemic immunity to an infectious agent.

    Lindsay J Hall, Simon Clare… in Journal of Immune Based Therapies and Vaccines (2010)

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