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  1. No Access

    Article

    NSun2 regulates aneurysm formation by promoting autotaxin expression and T cell recruitment

    Abdominal aortic aneurysm (AAA) is characterized by inflammatory cell infiltration and aggravated by hyperhomocysteinemia (HHcy). It is unknown whether the homocysteine (Hcy)-activated RNA methyltransferase NO...

    Yutong Miao, Yang Zhao, Lulu Han, **aolong Ma… in Cellular and Molecular Life Sciences (2021)

  2. No Access

    Article

    PKM2-dependent metabolic reprogramming in CD4+ T cells is crucial for hyperhomocysteinemia-accelerated atherosclerosis

    Inflammation mediated by activated T cells plays an important role in the initiation and progression of hyperhomocysteinemia (HHcy)-accelerated atherosclerosis in ApoE−/− mice. Homocysteine (Hcy) activates T cell...

    Silin Lü, Jiacheng Deng, Huiying Liu, Bo Liu, Juan Yang… in Journal of Molecular Medicine (2018)

  3. No Access

    Article

    Energy metabolism of T-lymphocytes and its biological significance

    Energy homeostasis is essential for maintaining cell survival and regular functions, and the loss of energy homeostasis may result in a variety of diseases. In this review, we focus on the roles and regulatory...

    Yi Yang, Juan Feng, Silin Lü, **an Wang in Science Bulletin (2016)

  4. Article

    Open Access

    Homocysteine activates T cells by enhancing endoplasmic reticulum-mitochondria coupling and increasing mitochondrial respiration

    Hyperhomocysteinemia (HHcy) accelerates atherosclerosis by increasing proliferation and stimulating cytokine secretion in T cells. However, whether homocysteine (Hcy)-mediated T cell activation is associated w...

    Juan Feng, Silin Lü, Yanhong Ding, Ming Zheng, **an Wang in Protein & Cell (2016)

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