7 Result(s)

Article

Safety, Tolerability, Pharmacokinetics and Initial Pharmacodynamics of a Subcommissural Organ-Spondin-Derived Peptide: A Randomized, Placebo-Controlled, Double-Blind, Single Ascending Dose First-in-Human Study

This randomized, double-blind, placebo-controlled study in healthy volunteers assessed the safety, tolerability, and pharmacokinetics of single ascending doses of intravenously administered NX210—a linear pept...

Valérie Bourdès, Peter Dogterom, André Aleman, Pierre Parmantier… in Neurology and Therapy (2022)

Article

Lack of collagen XV is protective after ischemic stroke in mice

Collagens are key structural components of basement membranes, providing a scaffold for other components or adhering cells. Collagens and collagen-derived active fragments contribute to biological activities s...

Hiramani Dhungana, Mikko T Huuskonen, Taina Pihlajaniemi… in Cell Death & Disease (2018)

Article

Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation

Ischemic stroke is one of the main causes of death and disability worldwide. It is caused by the cessation of cerebral blood flow resulting in the insufficient delivery of glucose and oxygen to the neural tiss...

Hiramani Dhungana, Mikko T. Huuskonen, Merja Jaronen… in Journal of Neuroinflammation (2017)

Article

Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy

Stroke is a highly debilitating, often fatal disorder for which current therapies are suitable for only a minor fraction of patients. Discovery of novel, effective therapies is hampered by the fact that advanc...

Mikko T. Huuskonen, Sanna Loppi, Hiramani Dhungana… in Scientific Reports (2016)

Article

Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis

Sighild Lemarchant, Yuriy Pomeshchik, Iurii Kidin… in Molecular Neurodegeneration (2016)

Article

ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis

A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) proteoglycanases are specialized in the degradation of chondroitin sulfate proteoglycans and participate in mechanisms mediating neuropla...

Sighild Lemarchant, Yuriy Pomeshchik, Iurii Kidin… in Molecular Neurodegeneration (2016)

Article

ADAMTS proteoglycanases in the physiological and pathological central nervous system

ADAMTS-1, -4, -5 and -9 belong to ‘a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)’ family and more precisely to the proteoglycanases subgroup based on their common ability to degrade c...

Sighild Lemarchant, Mathilde Pruvost, Joan Montaner… in Journal of Neuroinflammation (2013)