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Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection
Aftab Ansari and his colleagues show that antibody-mediated masking of α4β7 integrin impedes intravaginal transmission of simian immunodeficiency virus in macaques.
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Article
Host-Virus Interaction of ZIKA Virus in Modulating Disease Pathogenesis
The Zika virus (ZIKV) is a newly emerging pathogen that has resulted in a worldwide epidemic. It primarily spreads either through infected Aedes aegypti or Aedes albopictus mosquitos leading to severe neurologica...
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Article
Functional Meningeal Lymphatics and Cerebrospinal Fluid Outflow
Functional meningeal lymphatic system plays a crucial role in outflow of cerebrospinal fluid. Metabolites and neurotoxins in the cerebrospinal fluid may be excreted via this system and accumulate in the cervic...
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Article
FDC:TFH Interactions within Cervical Lymph Nodes of SIV-Infected Rhesus Macaques
Cerebrospinal fluid (CSF) drains via the lymphatic drainage pathway. This lymphatic pathway connects the central nervous system (CNS) to the cervical lymph node (CLN). As the CSF drains to CLN via the dural an...
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Article
In vivo characterization of macrophage-tropic simian immunodeficiency virus molecular clones in rhesus macaques
Macrophages are a major target of HIV/SIV infection and play an important role in pathogenesis by serving as viral reservoirs in the central nervous system. Previously, a unique early SIVmac251 envelope (Env) ...
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Article
Correction to: Zika Virus and the Metabolism of Neuronal Cells
The original version of this article unfortunately contained mistake.
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Article
Zika Virus and the Metabolism of Neuronal Cells
Zika virus (ZIKV) infection is associated with abnormal functions of neuronal cells causing neurological disorders such as microcephaly in the newborns and Guillain–Barré syndrome in the adults. Typically, hea...
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Article
SARS-CoV-2 Infection Leads to Neurological Dysfunction
A number of neurological disease complications have been seen following infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While most person with COVID-19 respiratory disease demo...
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Article
Infectivity of SARS-CoV-2: there Is Something More than D614G?
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Chronic Opioid Administration is Associated with Prevotella-dominated Dysbiosis in SIVmac251 Infected, cART-treated Macaques
People living with the human immunodeficiency virus (HIV) have an elevated risk of opioid misuse due to both prescriptions for HIV-associated chronic pain and because injection drug use remains a primary mode ...
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Article
Open AccessThe single-cell opioid responses in the context of HIV (SCORCH) consortium
Substance use disorders (SUD) and drug addiction are major threats to public health, impacting not only the millions of individuals struggling with SUD, but also surrounding families and communities. One of th...