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  1. Article

    Open Access

    Single-cell RNA-seq integrated with multi-omics reveals SERPINE2 as a target for metastasis in advanced renal cell carcinoma

    Tumor growth, metastasis and therapeutic response are believed to be regulated by the tumor and its microenvironment (TME) in advanced renal cell carcinoma (RCC). However, the mechanisms underlying genomic, tr...

    Wen-** Chen, Ke-qin Dong, **u-wu Pan, Si-shun Gan, Da Xu… in Cell Death & Disease (2023)

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  2. Article

    Open Access

    Heterogeneity of tumor microenvironment is associated with clinical prognosis of non-clear cell renal cell carcinoma: a single-cell genomics study

    Non-clear renal cell carcinomas (nccRCCs) are less frequent in kidney cancer with histopathological heterogeneity. A better understanding of the tumor biology of nccRCC can provide more effective treatment par...

    Wen-** Chen, Hao Cao, Jian-wei Cao, Li Zuo, Fa-jun Qu, Da Xu… in Cell Death & Disease (2022)

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  3. Article

    Open Access

    USP39 promotes malignant proliferation and angiogenesis of renal cell carcinoma by inhibiting VEGF-A165b alternative splicing via regulating SRSF1 and SRPK1

    The benefit of targeted therapy for renal cell carcinoma (RCC) is largely crippled by drug resistance. Rapid disease progression and poor prognosis occur in patients with drug resistance. New treatments demand...

    **u-wu Pan, Da Xu, Wen-** Chen, Jia-xin Chen, Wei-jie Chen… in Cancer Cell International (2021)

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