-
Article
The context-specific role of germline pathogenicity in tumorigenesis
Human cancers arise from environmental, heritable and somatic factors, but how these mechanisms interact in tumorigenesis is poorly understood. Studying 17,152 prospectively sequenced patients with cancer, we ...
-
Article
Open AccessComprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation
Lineage plasticity, the ability to transdifferentiate among distinct phenotypic identities, facilitates therapeutic resistance in cancer. In lung adenocarcinomas (LUADs), this phenomenon includes small cell an...
-
Article
Author Correction: Tumour lineage shapes BRCA-mediated phenotypes
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Tumour lineage shapes BRCA-mediated phenotypes
Mutations in BRCA1 and BRCA2 predispose individuals to certain cancers1–3, and disease-specific screening and preventative strategies have reduced cancer mortality in affected patients4,5. These classical tumour-...
-
Article
Open AccessEnhancing cancer clonality analysis with integrative genomics
It is understood that cancer is a clonal disease initiated by a single cell, and that metastasis, which is the spread of cancer from the primary site, is also initiated by a single cell. The seemingly natural ...
-
Article
Open AccessLeveraging the new with the old: providing a framework for the integration of historic microarray studies with next generation sequencing
Next Generation Sequencing (NGS) methods are rapidly providing remarkable advances in our ability to study the molecular profiles of human cancers. However, the scientific discovery offered by NGS also include...
-
Article
Open AccessRevealing the inherent heterogeneity of human malignancies by variant consensus strategies coupled with cancer clonal analysis
Tumors are heterogeneous in composition. They are composed of cancer cells proper, along with stromal elements that collectively form a microenvironment, all of which are necessary to nurture the malignant pro...
-
Article
Open AccessTowards the integration, annotation and association of historical microarray experiments with RNA-seq
Transcriptome analysis by microarrays has produced important advances in biomedicine. For instance in multiple myeloma (MM), microarray approaches led to the development of an effective disease subty** via c...
-
Article
Overview of biological database map** services for interoperation between different 'omics' datasets
Many primary biological databases are dedicated to providing annotation for a specific type of biological molecule such as a clone, transcript, gene or protein, but often with limited cross-references. Therefo...
-
Article
Open AccessNATbox: a network analysis toolbox in R
There has been recent interest in capturing the functional relationships (FRs) from high-throughput assays using suitable computational techniques. FRs elucidate the working of genes in concert as a system as ...
