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Article
The Role of HSP90 Molecular Chaperones in Depression: Potential Mechanisms
Major depressive disorder (MDD) is characterized by high rates of disability and death and has become a public health problem that threatens human life and health worldwide. HPA axis disorder and neuroinflamma...
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Article
Controlled release of phosphorus-containing free radical from the porous channels of metal–organic frame to reduce the combustion heat and smoke releases of polystyrene
The combustion of polystyrene (PS) releases enormous amounts of smoke and heat, which seriously affects individuals and property safety. This research employed a porous metal–organic framework (P-Fe-MOF) with ...
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Article
Targeting JMJD1C to selectively disrupt tumor Treg cell fitness enhances antitumor immunity
Regulatory T (Treg) cells are critical for immune tolerance but also form a barrier to antitumor immunity. As therapeutic strategies involving Treg cell depletion are limited by concurrent autoimmune disorders, i...
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Article
Quercetin Ameliorates Cognitive Impairment in Depression by Targeting HSP90 to Inhibit NLRP3 Inflammasome Activation
Cognitive dysfunction was a common symptom of major depressive disorder (MDD). In previous studies, psychological stress leads to activation and proliferation of microglial cells in different brain regions. Qu...
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Article
Pretreatment lymphocyte-monocyte ratio (LMR) as a superior predictor of short-term progression outcomes in patients with gastric cancer receiving second- and later-line apatinib regimens
Lymphocyte-monocyte ratio (LMR) has previously been used as a prognostic predictor in various solid tumors. This research aims in comparing the prognostic predictive Please check and conability of several infl...
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Article
Blood–Brain Barrier Dysfunction in the Pathogenesis of Major Depressive Disorder
Major depression represents a complex and prevalent psychological disease that is characterized by persistent depressed mood, impaired cognitive function and complicated pathophysiological and neuroendocrine a...
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Article
Jmjd1c demethylates STAT3 to restrain plasma cell differentiation and rheumatoid arthritis
Appropriate regulation of B cell differentiation into plasma cells is essential for humoral immunity while preventing antibody-mediated autoimmunity; however, the underlying mechanisms, especially those with p...
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Article
Research Progress of FeSe-based Superconductors Containing Ammonia/Organic Molecules Intercalation
As an important part of Fe-based superconductors, FeSe-based superconductors have become a hot field in condensed matter physics. The exploration and preparation of such superconducting materials form the basi...
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Article
Protein Aggregation in the Pathogenesis of Ischemic Stroke
Despite the distinction between ischemic stroke and neurodegenerative disorders, they share numerous pathophysiologies particularly those mediated by inflammation and oxidative stress. Although protein aggrega...
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Article
Beta- and Novel Delta-Coronaviruses Are Identified from Wild Animals in the Qinghai-Tibetan Plateau, China
Outbreaks of severe virus infections with the potential to cause global pandemics are increasingly concerning. One type of those commonly emerging and re-emerging pathogens are coronaviruses (SARS-CoV, MERS-Co...
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Article
Immunization with recombinant baculovirus expressing the VP6 protein of grass carp reovirus induces immunity in grass carp