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  1. No Access

    Article

    The Role of HSP90 Molecular Chaperones in Depression: Potential Mechanisms

    Major depressive disorder (MDD) is characterized by high rates of disability and death and has become a public health problem that threatens human life and health worldwide. HPA axis disorder and neuroinflamma...

    Xuyuan Fan, Lei Sun, Ye Qin, Yuan Liu, Shusheng Wu, Longfei Du in Molecular Neurobiology (2024)

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    Article

    Quercetin Ameliorates Cognitive Impairment in Depression by Targeting HSP90 to Inhibit NLRP3 Inflammasome Activation

    Cognitive dysfunction was a common symptom of major depressive disorder (MDD). In previous studies, psychological stress leads to activation and proliferation of microglial cells in different brain regions. Qu...

    Longfei Du, Xuyuan Fan, Yi Yang, Shusheng Wu, Yuan Liu in Molecular Neurobiology (2024)

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    Article

    Blood–Brain Barrier Dysfunction in the Pathogenesis of Major Depressive Disorder

    Major depression represents a complex and prevalent psychological disease that is characterized by persistent depressed mood, impaired cognitive function and complicated pathophysiological and neuroendocrine a...

    Shusheng Wu, Yuye Yin, Longfei Du in Cellular and Molecular Neurobiology (2022)

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    Article

    Protein Aggregation in the Pathogenesis of Ischemic Stroke

    Despite the distinction between ischemic stroke and neurodegenerative disorders, they share numerous pathophysiologies particularly those mediated by inflammation and oxidative stress. Although protein aggrega...

    Shusheng Wu, Longfei Du in Cellular and Molecular Neurobiology (2021)