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Article
Open AccessFlexible generation of structured terahertz fields via programmable exchange-biased spintronic emitters
Structured light, particularly in the terahertz frequency range, holds considerable potential for a diverse range of applications. However, the generation and control of structured terahertz radiation pose maj...
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Article
Open AccessNingetinib, a novel FLT3 inhibitor, overcomes secondary drug resistance in acute myeloid leukemia
FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is a common mutation type in acute myeloid leukemia (AML) and is usually associated with poor patient prognosis. With advancements in molecular...
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Article
Open AccessDislocation response of ECC-RC composite supporting structures of tunnels passing through active fault
To address the problems of the conventional composite supporting structures (CCSSs) such as insufficient anti-dislocation performance and deformation capacity, this study used Engineered Cementitious Composite...
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Article
Open AccessThe circadian gene ARNTL2 promotes nasopharyngeal carcinoma invasiveness and metastasis through suppressing AMOTL2-LATS-YAP pathway
Metastasis is the major culprit of treatment failure in nasopharyngeal carcinoma (NPC). Aryl hydrocarbon receptor nuclear translocator like 2 (ARNTL2), a core circadian gene, plays a crucial role in the develo...
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Article
Open AccessDe novo design of proteins housing excitonically coupled chlorophyll special pairs
Natural photosystems couple light harvesting to charge separation using a ‘special pair’ of chlorophyll molecules that accepts excitation energy from the antenna and initiates an electron-transfer cascade. To ...
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Article
Open AccessInvestigating the three-dimensional myocardial micro-architecture in the laminar structure using X-ray phase-contrast microtomography
A comprehensive grasp of the myocardial micro-architecture is essential for understanding diverse heart functions. This study aimed to investigate three-dimensional (3D) cardiomyocyte arrangement in the lamina...
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Article
Open AccessA cell atlas of the adult female Aedes aegypti midgut revealed by single-cell RNA sequencing
Aedes aegypti is a primary vector for transmitting various arboviruses, including Yellow fever, dengue and Zika virus. The mosquito midgut is the principal organ for blood meal digestion, nutrient absorption and ...
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Article
Open AccessEpigallocatechin gallate modulates ferroptosis through downregulation of tsRNA-13502 in non-small cell lung cancer
Ferroptosis, an iron-dependent regulated cell death mechanism, holds significant promise as a therapeutic strategy in oncology. In the current study, we explored the regulatory effects of epigallocatechin gall...
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Article
Open AccessSimhypo-sand: a simple hypoplastic model for granular materials and SPH implementation
This paper introduces a new hypoplastic model characterized by a simple and elegant formulation. It requires only 7 material parameters to depict salient mechanical behaviors of granular materials. The numeric...
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Article
Open AccessDo not stumble over the same “stone” twice: a case series of endogenous endophthalmitis secondary to severe systemic diseases
Endogenous endophthalmitis (EE) is a rare but highly destructive eye emergency secondary to systemic infection. Acute endophthalmitis can lead to irreversible vision impairment or even loss of the whole eye, u...
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Article
Open AccessRecurrent neural network for predicting absence of heterozygosity from low pass WGS with ultra-low depth
The absence of heterozygosity (AOH) is a kind of genomic change characterized by a long contiguous region of homozygous alleles in a chromosome, which may cause human genetic disorders. However, no method of l...
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Article
Open AccessSource identification and driving factor apportionment for soil potentially toxic elements via combining APCS-MLR, UNMIX, PMF and GDM
The contamination and quantification of soil potentially toxic elements (PTEs) contamination sources and the determination of driving factors are the premise of soil contamination control. In our study, 788 so...
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Open AccessCamrelizumab plus famitinib in previously chemo-immunotherapy treated patients with advanced NSCLC: results from an open-label multicenter phase 2 basket study
The combination of immune checkpoint inhibitors and antiangiogenic agents has been effective in treating multiple cancers. This was further explored in an open-label, multicenter phase 2 basket study (NCT04346...
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Article
Correction: Exploring Preclinical Experiments with Different Fat Types for Autologous Fat Grafting
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Open AccessSpatial distribution characteristics of soil heavy metals in Sabao Chaqu watershed of Tuotuo river, Qinghai-Tibet Plateau based on geographic detector
The Qinghai-Tibet Plateau belongs to the area of extremely fragile environment and sensitive to human activities. In recent years, more and more human interference has been detected in this area. In this study...
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Open AccessA phase II study of belumosudil for chronic graft-versus-host disease in patients who failed at least one line of systemic therapy in China
Chronic graft-versus-host disease (cGVHD) is an immune-related disorder that is the most common complication post-allogenic hematopoietic stem cell transplant. Corticosteroids with or without calcineurin inhib...
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Article
Open AccessA restricted dynamic surface self-reconstruction toward high-performance of direct seawater oxidation
The development of highly efficient electrocatalysts for direct seawater splitting with bifunctionality for inhibiting anodic oxidation reconstruction and selective oxygen evolution reactions is a major challe...
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Article
Open AccessDeficiency of skeletal muscle Agrin contributes to the pathogenesis of age-related sarcopenia in mice
Sarcopenia, a progressive and prevalent neuromuscular disorder, is characterized by age-related muscle wasting and weakening. Despite its widespread occurrence, the molecular underpinnings of this disease rema...
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Article
Open AccessAlpha5 nicotine acetylcholine receptor subunit promotes intrahepatic cholangiocarcinoma metastasis
Neurotransmitter-initiated signaling pathway were reported to play an important role in regulating the malignant phenotype of tumor cells. Cancer cells could exhibit a “neural addiction” property and build up ...
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Article
Open AccessUnrelated donor hematopoietic stem cell transplantation compared to immunosuppressive therapy plus eltrombopag as first-line treatment for adults with severe aplastic anemia
