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    Article

    Exosomal MMP-1 transfers metastasis potential in triple-negative breast cancer through PAR1-mediated EMT

    Triple-negative breast cancer (TNBC) is a subtype of breast cancer with high risk of distant metastasis, in which the intercellular communication between tumor cells also plays a role. Exosomes can be released...

    Yihui Zhu, Zhonghua Tao, Ying Chen, Shuchen Lin in Breast Cancer Research and Treatment (2022)

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    Open Access

    Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro

    Ubiquitin specific peptidase 39 (USP39), an essential factor in the assembly of the mature spliceosome complex, has an aberrant expression in several cancer. However, its function and the corresponding mechani...

    Zhihua Gan, Kun Han, Shuchen Lin, Haiyan Hu, Zan Shen, Daliu Min in Biological Research (2017)

  3. Article

    Open Access

    Selumetinib suppresses cell proliferation, migration and trigger apoptosis, G1 arrest in triple-negative breast cancer cells

    Triple-negative breast cancer (TNBC) has aggressive progression with poor prognosis and ineffective treatments. Selumetinib is an allosteric, ATP-noncompetitive inhibitor of MEK1/2, which has benn known as eff...

    Yan Zhou, Shuchen Lin, Kuo-Fu Tseng, Kun Han, Yaling Wang, Zhi-hua Gan in BMC Cancer (2016)