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Open AccessEstimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression
Single-cell RNA sequencing studies have suggested that total mRNA content correlates with tumor phenotypes. Technical and analytical challenges, however, have so far impeded at-scale pan-cancer examination of ...
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Protocol
MuSE: A Novel Approach to Mutation Calling with Sample-Specific Error Modeling
Accurate detection of somatic mutations in genetically heterogeneous tumor cell populations using next-generation sequencing remains challenging. We have developed MuSE, Mutation calling using a Markov Substituti...
