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Article
Open AccessDesign, synthesis and anticancer activities evaluation of novel pyrazole modified catalpol derivatives
Catalpol, a natural product mainly existed in plenty of Chinese traditional medicines, is an iridoid compound with the comprehensive effects on neuroprotective, anti-inflammatory, choleretic, hypoglycemic and ...
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Article
Open AccessDesign, microwave synthesis, and molecular docking studies of catalpol crotonates as potential neuroprotective agent of diabetic encephalopathy
Catalpol has gained increasing attention for its potential contributions in controlling glycolipid metabolism and diabetic complications, which makes used as a very promising scaffold for seeking new anti-diab...
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Article
Open AccessTissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant
A noncoding polymorphism (rs78378222) in TP53, carried by scores of millions of people, was previously associated with moderate risk of brain tumors and other neoplasms. We find a positive association between thi...
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Article
Open AccessDesign, synthesis, and preliminary biological evaluation of catalpol propionates as antiaging drugs
In this paper, catalpol propionylated analogs (CPs) were designed as drug ligands of glutathione peroxidase (GSH-Px) based on molecular docking (MD) using Surflex-Docking method. The calculated total scores (T...
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Article
Berberine Attenuates Cigarette Smoke-Induced Acute Lung Inflammation
Berberine (Ber), the major constituent of Coptidis Rhizoma, possesses anti-inflammatory properties. In this study, we investigated the effects of Ber on cigarette smoke (CS)-mediated acute lung inflammation. C...
