5 Result(s)
within
Shu-Hui Liu
Science, Humanities and Social Sciences, multidisciplinary
-
Article
Open AccessAuthor Correction: Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Open AccessTargeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer
Human CLDN18.2 is highly expressed in a significant proportion of gastric and pancreatic adenocarcinomas, while normal tissue expression is limited to the epithelium of the stomach. The restricted expression m...
-
Article
Open AccessOptimal design, anti-tumour efficacy and tolerability of anti-CXCR4 antibody drug conjugates
Antibody-drug conjugates (ADCs) are promising therapies for haematological cancers. Historically, their therapeutic benefit is due to ADC targeting of lineage-restricted antigens. The C-X-C motif chemokine recept...
-
Article
Open AccessTargeting primary acute myeloid leukemia with a new CXCR4 antagonist IgG1 antibody (PF-06747143)
The chemokine receptor CXCR4 mediates cell anchorage in the bone marrow (BM) microenvironment and is overexpressed in 25–30% of patients with acute myeloid leukemia (AML). Here we have shown that a new CXCR4 r...
-
Article
Clathrin self-assembly is mediated by a tandemly repeated superhelix
Clathrin is a triskelion-shaped cytoplasmic protein that polymerizes into a polyhedral lattice on intracellular membranes to form protein-coated membrane vesicles. Lattice formation induces the sorting of memb...
