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Open AccessAuthor Correction: Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessRegular exercise and the trajectory of health-related quality of life among Taiwanese adults: a cohort study analysis 2006–2014
Physical activity is related to health-related quality of life, but little evidence from multiple waves of panel data in Asian countries area available. This study aims to explore the impacts of different degr...
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Open AccessSpironolactone ameliorates endothelial dysfunction through inhibition of the AGE/RAGE axis in a chronic renal failure rat model
Spironolactone can improve endothelial dysfunction in the setting of heart failure and diabetes models. However, its beneficial effect in the cardiovascular system is not clear in the setting of non-diabetic r...
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Open AccessTargeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer
Human CLDN18.2 is highly expressed in a significant proportion of gastric and pancreatic adenocarcinomas, while normal tissue expression is limited to the epithelium of the stomach. The restricted expression m...
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Open AccessOptimal design, anti-tumour efficacy and tolerability of anti-CXCR4 antibody drug conjugates
Antibody-drug conjugates (ADCs) are promising therapies for haematological cancers. Historically, their therapeutic benefit is due to ADC targeting of lineage-restricted antigens. The C-X-C motif chemokine recept...
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Open AccessTargeting primary acute myeloid leukemia with a new CXCR4 antagonist IgG1 antibody (PF-06747143)
The chemokine receptor CXCR4 mediates cell anchorage in the bone marrow (BM) microenvironment and is overexpressed in 25–30% of patients with acute myeloid leukemia (AML). Here we have shown that a new CXCR4 r...
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Open AccessTargeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia
The CXCR4-CXCL12 axis plays an important role in the chronic lymphocytic leukemia (CLL)-microenvironment interaction. Overexpression of CXCR4 has been reported in different hematological malignancies including...
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Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading
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Alkaline phosphatase activity and its relationship to soil properties in a saline–sodic soil reclaimed by crop** wolfberry (Lycium barbarum L.) with drip irrigation
In order to ascertain the alkaline phosphatase (ALP) activity and its relationship with soil properties in saline–sodic soils during reclamation, a study was conducted in a saline–sodic soil reclaimed by cropp...
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Open AccessLapatinib–induced NF-kappaB activation sensitizes triple-negative breast cancer cells to proteasome inhibitors
Triple-negative breast cancer (TNBC), a subtype of breast cancer with negative expressions of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2), is frequently diagno...
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Morphological and molecular cytogenetic characterization of partial octoploid Tritileymus
This study used cytological observation, genomic in situ hybridization (GISH), and seed storage protein electrophoresis to characterize a partial octoploid Tritileymus M842-1 derived from Leymus m...
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Development and identification of a wheat-Leymus mollis multiple alien substitution line
Leymus mollis (Trin.) Pilger is resistant to drought, cold, and many fungal and bacterial diseases, and it grows well on barren and salty soils. It has short, strong stems and large spikes with m...
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Effect of drip irrigation on soil nutrients changes of saline–sodic soils in the Songnen Plain
A field experiment was carried out to research the changes and spatial distributions of soil nutrients in saline–sodic soil for different number of cultivated years under drip irrigation. The distributions of ...
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Assessment of soil enzyme activities of saline–sodic soil under drip irrigation in the Songnen plain
A field experiment was carried out to research the changes and spatial distributions of soil enzyme activities in saline–sodic soil for a different number of cultivated years under drip irrigation. The distrib...
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Development and identification of a wheat-Psathyrostachys huashanica addition line carrying HMW-GS, LMW-GS and gliadin genes
Psathyrostachys huashanica Keng, in the family Poaceae, subtribe Triticeae is an endangered and endemic species of China. It is characterized as Shaanxi, drought tolerant and fungus and disease resistant. In this...
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Relaxin bioassays
A well-characterized biotechnology product is a protein whose identity, purity, impurities, potency, and quantity can be determined and controlled. Implicit in this definition is the ability to define the biol...
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Clathrin self-assembly is mediated by a tandemly repeated superhelix
Clathrin is a triskelion-shaped cytoplasmic protein that polymerizes into a polyhedral lattice on intracellular membranes to form protein-coated membrane vesicles. Lattice formation induces the sorting of memb...
