-
Article
Open AccessInterpretable machine learning model for early prediction of 28-day mortality in ICU patients with sepsis-induced coagulopathy: development and validation
Sepsis-induced coagulopathy (SIC) is extremely common in individuals with sepsis, significantly associated with poor outcomes. This study attempted to develop an interpretable and generalizable machine learnin...
-
Article
Effect of internal and external chaotic stimuli on synchronization of piezoelectric auditory neurons in coupled time-delay systems
Hearing impairment is considered to be related to the damage of hair cells or synaptic terminals, which will cause varying degrees of hearing loss. Numerous studies have shown that cochlear implants can balanc...
-
Article
Open AccessTowards precision medicine based on a continuous deep learning optimization and ensemble approach
We developed a continuous learning system (CLS) based on deep learning and optimization and ensemble approach, and conducted a retrospective data simulated prospective study using ultrasound images of breast m...
-
Article
Open AccessThe significant role of redox system in myeloid leukemia: from pathogenesis to therapeutic applications
Excessive generation of reactive oxygen species (ROS) in the presence of a defective antioxidant system can induce cellular damage and disrupt normal physiological functions. Several studies have revealed the ...
-
Article
C-terminal of E1A binding protein 2 promotes the malignancy of osteosarcoma cells via JAK1/Stat3 signaling
Previous studies have demonstrated that the C-terminal of E1A binding proteins (CtBPs) influences tumorigenesis by participating in cell signal transduction in various human malignancies. However, the detailed...
-
Article
MicroRNA-29b-3p Targets SPARC Gene to Protect Cardiocytes against Autophagy and Apoptosis in Hypoxic-Induced H9c2 Cells
MicroRNAs participate in the regulation of abnormal cardiomyocyte apoptosis and autophagy, which leads to heart failure (HF). Lower miR-29b-3p levels were found in HF patients in this study. However, the role ...
-
Article
Flanker paradigm contains conflict and distraction factors with distinct neural mechanisms: an ERP analysis in a 2-1 map** task
Behavioral studies using the flanker 2-1 map** task suggest that both stimulus and response conflicts contribute to flanker conflict effect. However, both are intertwined with distraction effect. Their under...