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  1. Article

    Open Access

    Interpretable machine learning model for early prediction of 28-day mortality in ICU patients with sepsis-induced coagulopathy: development and validation

    Sepsis-induced coagulopathy (SIC) is extremely common in individuals with sepsis, significantly associated with poor outcomes. This study attempted to develop an interpretable and generalizable machine learnin...

    Shu Zhou, Zongqing Lu, Yu Liu, Minjie Wang in European Journal of Medical Research (2024)

  2. No Access

    Article

    Effect of internal and external chaotic stimuli on synchronization of piezoelectric auditory neurons in coupled time-delay systems

    Hearing impairment is considered to be related to the damage of hair cells or synaptic terminals, which will cause varying degrees of hearing loss. Numerous studies have shown that cochlear implants can balanc...

    Guodong Huang, Shu Zhou, Rui Zhu, Yunhai Wang, Yuan Chai in Cognitive Neurodynamics (2023)

  3. Article

    Open Access

    Towards precision medicine based on a continuous deep learning optimization and ensemble approach

    We developed a continuous learning system (CLS) based on deep learning and optimization and ensemble approach, and conducted a retrospective data simulated prospective study using ultrasound images of breast m...

    Jian Li, Linyuan **, Zhiyuan Wang, Qinghai Peng, Yueai Wang in npj Digital Medicine (2023)

  4. Article

    Open Access

    The significant role of redox system in myeloid leukemia: from pathogenesis to therapeutic applications

    Excessive generation of reactive oxygen species (ROS) in the presence of a defective antioxidant system can induce cellular damage and disrupt normal physiological functions. Several studies have revealed the ...

    Natasha Mupeta Kaweme, Shu Zhou, Geoffrey Joseph Changwe, Fuling Zhou in Biomarker Research (2020)

  5. No Access

    Article

    C-terminal of E1A binding protein 2 promotes the malignancy of osteosarcoma cells via JAK1/Stat3 signaling

    Previous studies have demonstrated that the C-terminal of E1A binding proteins (CtBPs) influences tumorigenesis by participating in cell signal transduction in various human malignancies. However, the detailed...

    Pengyun Wang, Benfeng Yu, Chengyan Wang in Journal of Cell Communication and Signaling (2020)

  6. No Access

    Article

    MicroRNA-29b-3p Targets SPARC Gene to Protect Cardiocytes against Autophagy and Apoptosis in Hypoxic-Induced H9c2 Cells

    MicroRNAs participate in the regulation of abnormal cardiomyocyte apoptosis and autophagy, which leads to heart failure (HF). Lower miR-29b-3p levels were found in HF patients in this study. However, the role ...

    Shu Zhou, Dazhou Lei, Faqin Bu in Journal of Cardiovascular Translational Re… (2019)

  7. No Access

    Article

    Flanker paradigm contains conflict and distraction factors with distinct neural mechanisms: an ERP analysis in a 2-1 map** task

    Behavioral studies using the flanker 2-1 map** task suggest that both stimulus and response conflicts contribute to flanker conflict effect. However, both are intertwined with distraction effect. Their under...

    Shu Zhou, Shenglan **ong, Wenwen Cheng, You Wang in Cognitive Neurodynamics (2019)