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Open AccessComparison of nalbuphine versus magnesium sulfate as an adjuvant to intrathecal hyperbaric bupivacaine (0.5%) in infraumbilical surgeries
Spinal anesthesia with bupivacaine is very common for infraumbilical surgeries. Various adjuvants are added to it to improve the quality of the block and post-operative analgesia. The study period for this stu...
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Recent Trends and Advances
Targeted customization of genome has given us the ability to study gene function, make highly specific correction in genes or even introduce or insert DNA sequence. A variety of enzymes, transcription factors,...
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Article
Open AccessCorrection to: Alzheimer’s genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessAlzheimer’s genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner
Although APP metabolism is being intensively investigated, a large fraction of its modulators is yet to be characterized. In this context, we combined two genome-wide high-content screenings to assess the func...
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Host-dependent molecular factors mediating SARS-CoV-2 infection to gain clinical insights for develo** effective targeted therapy
Coronavirus disease 2019 (COVID-19), a recent viral pandemic that first began in December 2019, in Hunan wildlife market, Wuhan, China. The infection is caused by a coronavirus, SARS-CoV-2 and clinically chara...
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Open AccessComparative study of intrathecal preservative-free midazolam versus nalbuphine as an adjuvant to intrathecal bupivacaine (0.5%) in patients undergoing elective lower-segment caesarean section
Intrathecal anesthesia is common for parturients undergoing lower-segment caesarean section. Various adjuvants are added to intrathecal bupivacaine for potentiating pharmacological effects, improving quality o...
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Article
Open AccessBIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation
The bridging integrator 1 gene (BIN1) is a major genetic risk factor for Alzheimer’s disease (AD). In this report, we investigated how BIN1-dependent pathophysiological processes might be associated with Tau. We ...
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Article
kinship across species: learning to care for nonhuman others
This essay responds to Donna J. Haraway’s (2016) provocation to ‘stay with the trouble’ of learning to live well with nonhumans as kin, through practice-based approaches to learning to care for nonhuman others. T...
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Open AccessGenome-wide, high-content siRNA screening identifies the Alzheimer’s genetic risk factor FERMT2 as a major modulator of APP metabolism
Genome-wide association studies (GWASs) have identified 19 susceptibility loci for Alzheimer’s disease (AD). However, understanding how these genes are involved in the pathophysiology of AD is one of the main ...
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Article
Waveform Classification and Water-Land Transition over the Brahmaputra River using SARAL/AltiKa & Jason-2 Altimeter
With technology development and reduced foot print size of recent altimeters, estimation of water level height of inland water bodies with sub-meter level accuracy at the global scale with reasonable temporal ...
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Article
Receptor tyrosine kinase ErbB2 translocates into mitochondria and regulates cellular metabolism
It is well known that ErbB2, a receptor tyrosine kinase, localizes to the plasma membrane. Here we describe a novel observation that ErbB2 also localizes in mitochondria of cancer cells and patient samples. We...
