3 Result(s)
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Article
Open AccessSingle-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity
Obesity promotes diverse pathologies, including atherosclerosis and dementia, which frequently involve vascular defects and endothelial cell (EC) dysfunction. Each organ has distinct EC subtypes, but whether E...
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Article
Open AccessActivated protein C reverses epigenetically sustained p66Shc expression in plaque-associated macrophages in diabetes
Impaired activated protein C (aPC) generation is associated with atherosclerosis and diabetes mellitus. Diabetes-associated atherosclerosis is characterized by the hyperglycaemic memory, e.g., failure of disea...
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Article
Open Accessp45 NF-E2 regulates syncytiotrophoblast differentiation by post-translational GCM1 modifications in human intrauterine growth restriction
Placental insufficiency jeopardizes prenatal development, potentially leading to intrauterine growth restriction (IUGR) and stillbirth. Surviving fetuses are at an increased risk for chronic diseases later in ...
