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Article
Open AccessSingle-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity
Obesity promotes diverse pathologies, including atherosclerosis and dementia, which frequently involve vascular defects and endothelial cell (EC) dysfunction. Each organ has distinct EC subtypes, but whether E...
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Article
Open AccessReversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression
A major obstacle in diabetes is the metabolic or hyperglycemic memory, which lacks specific therapies. Here we show that glucose-mediated changes in gene expression largely persist in diabetic kidney disease (...
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Article
Open AccessActivated protein C reverses epigenetically sustained p66Shc expression in plaque-associated macrophages in diabetes
Impaired activated protein C (aPC) generation is associated with atherosclerosis and diabetes mellitus. Diabetes-associated atherosclerosis is characterized by the hyperglycaemic memory, e.g., failure of disea...
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Article
Open AccessActivated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
Graft-vs.-host disease (GvHD) is a major complication of allogenic hematopoietic stem-cell(HSC) transplantation. GvHD is associated with loss of endothelial thrombomodulin, but the relevance of this for the ad...
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Article
Open Accessp45 NF-E2 regulates syncytiotrophoblast differentiation by post-translational GCM1 modifications in human intrauterine growth restriction
Placental insufficiency jeopardizes prenatal development, potentially leading to intrauterine growth restriction (IUGR) and stillbirth. Surviving fetuses are at an increased risk for chronic diseases later in ...
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The Role of Platelets During Development and Reproduction
Platelets are an essential component of the hemostatic system in non-pregnant and more so in pregnant women. Low platelet counts during pregnancy can be harmful both to the mother and the fetus and can lead to...
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Article
Open AccessStabilization of endogenous Nrf2 by minocycline protects against Nlrp3-inflammasome induced diabetic nephropathy
While a plethora of studies support a therapeutic benefit of Nrf2 activation and ROS inhibition in diabetic nephropathy (dNP), the Nrf2 activator bardoxolone failed in clinical studies in type 2 diabetic patie...
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Article
Open AccessDefective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy
Endoplasmic reticulum (ER) stress is associated with diabetic nephropathy (DN), but its pathophysiological relevance and the mechanisms that compromise adaptive ER signalling in podocytes remain unknown. Here ...
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Chapter
Hydrogen Peroxide Sensing and Signaling
H2O2 has been found to act as a signaling molecule and secondary messenger in many signal transduction pathways like in insulin signaling, cell proliferation, and apoptosis. There are biological sensors which sen...
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Chapter
MMPs in Cardiovascular Diseases: Emerging Pharmacological Targets
Matrix metalloproteinases (MMPs), a family of proteolytic enzymes important in the degradation and turnover of extracellular matrix (ECM) components, result in geometric and structural changes of the myocardiu...
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Article
Cell in situ zymography: an in vitro cytotechnology for localization of enzyme activity in cell culture
In situ zymography is a unique technique for detection and localization of enzyme–substrate interactions majorly in histological sections. Substrate with quenched fluorogenic molecule is incorporated in gel ov...
