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Allogeneic stem cell transplantation for inherited metabolic disorders: 35 years’ experience at a single institution
Hematopoietic stem cell transplants for inherited metabolic disorders performed at Tokai University Hospital between June 5, 1986, and May 28, 2021, were analyzed and compared between the period before 2007 an...
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Article
Prevalence of osteosarcopenia and its association with mortality and fractures among patients undergoing hemodialysis
Osteosarcopenia is an age-related syndrome characterized by the coexistence of osteoporosis and sarcopenia. Little is known about the clinical implications of osteosarcopenia among patients undergoing hemodial...
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Article
TBI, etoposide, and cyclophosphamide conditioning for intermediate-risk relapsed childhood acute lymphoblastic leukemia
In children with intermediate-risk relapsed acute lymphoblastic leukemia (ALL), allogeneic hematopoietic stem cell transplantation (allo-HSCT) has markedly improved the outcome of patients with an unsatisfacto...
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Article
Open AccessMolecular basis promoting centriole triplet microtubule assembly
The triplet microtubule, a core structure of centrioles crucial for the organization of centrosomes, cilia, and flagella, consists of unclosed incomplete microtubules. The mechanisms of its assembly represent ...
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Article
Open AccessUtility of the low physical activity questionnaire for hemodialysis patients with frailty: a cross-sectional study
The low physical activity questionnaire (LoPAQ), which has been developed to assess the low levels of physical activity in patients on dialysis, is so far available only in English. Moreover, no study has exam...
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Article
Open AccessThe association between living alone and depressive symptoms and the role of pet ownership among Japanese workers
Living alone has been positively associated with the prevalence of depressive symptoms. We examined how a combination of living alone and pet ownership relates to depressive symptoms.
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Article
Effects of anthropometric changes on hospitalization and mortality among patients on hemodialysis
Low values for anthropometric indicators are risk factors for adverse clinical outcomes among patients on hemodialysis. Nonetheless, little is known about the association between the trajectory of anthropometr...
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Article
Open AccessThe association between experience of COVID-19-related discrimination and psychological distress among healthcare workers for six national medical research centers in Japan
Discrimination is an important determinant of negative mental health outcomes. This study determined the association between the experience of COVID-19-related discrimination and psychological distress among h...
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Article
Open AccessHaplotype-resolved chromosomal-level assembly of wasabi (Eutrema japonicum) genome
In Japan, wasabi (Eutrema japonicum) is an important traditional condiment, and is recognized as an endemic species. In the present study, we generated a chromosome-level and haplotype-resolved reference genome f...
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Open AccessInteractional effects of depressive symptoms and physical function on daily physical activity in ambulatory patients receiving hemodialysis
Clarification of the factors associated with decreased physical activity is crucial for effective disease management in patients undergoing hemodialysis. Although evidence suggests that physical activity may b...
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Article
Open AccessOmicron BA.1 neutralizing antibody response following Delta breakthrough infection compared with booster vaccination of BNT162b2
Longitudinal data are lacking to compare booster effects of Delta breakthrough infection versus third vaccine dose on neutralizing antibodies (NAb) against Omicron.
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Article
Open AccessDifferent associations of occupational and leisure-time physical activity with the prevalence of hypertension among middle-aged community dwellers in rural Khánh Hòa, Vietnam
In contrast to high-income countries where physical activity (PA), particularly leisure-time PA, has been shown to be protective against hypertension, few studies have been conducted in low- and middle-income ...
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Article
Antibody responses and correlates after two and three doses of BNT162b2 COVID-19 vaccine
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Heated tobacco product use and abnormal glucose metabolism: a working population-based study
We aimed to assess the cross-sectional association of heated tobacco product (HTP) use with prediabetes and diabetes.
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Open AccessChanges in body composition of patients undergoing hemodialysis during the coronavirus disease 2019 pandemic: a retrospective longitudinal study
The spread of coronavirus disease 2019 (COVID-19) has dramatically altered the lifestyles of many people worldwide. Several studies reported that body weight of young adults increased during the COVID-19 pande...
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Article
Open AccessHeated tobacco products and circulating high-density lipoprotein cholesterol concentrations
We aimed to assess the association between heated tobacco product (HTP) use and high-density lipoprotein cholesterol (HDL-C) concentration. Our study included 12,268 workers from five companies (Study I) and 3...
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Article
Open AccessMetabolic syndrome and the immunogenicity of Pfizer–BioNTech vaccine: a cross-sectional study in Japanese healthcare workers
The clustering of metabolic abnormalities may weaken vaccine-induced immunity, but epidemiological data regarding SARS-CoV-2 vaccines are scarce. The present study aimed to examine the cross-sectional associat...
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Natural inhibitors for severe acute respiratory syndrome coronavirus 2 main protease from Moringa oleifera, Aloe vera, and Nyctanthes arbor-tristis: molecular docking and ab initio fragment molecular orbital calculations
The novel coronavirus 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly worldwide, and new drug treatments for COVID-19 are urgently required. To find th...
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Article
Open AccessSARS-CoV-2 specific T cell and humoral immune responses upon vaccination with BNT162b2: a 9 months longitudinal study
The humoral and cellular immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upon the coronavirus disease 2019 (COVID-19) vaccination remain to be clarified. Hence, we aimed t...
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Open AccessRelationship between psychiatric symptoms and activities of daily living in patients undergoing hemodialysis
Accurately identifying the factors contributing to decline in activities of daily living (ADL) is important for preventing such decline in patients undergoing hemodialysis (HD). We studied the prevalence and n...