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    Canagliflozin Inhibits Glioblastoma Growth and Proliferation by Activating AMPK

    Sodium-glucose transporter 2 (SGLT2) inhibitors are antidiabetic drugs affecting SGLT2. Recent studies have shown various cancers expressing SGLT2, and SGLT2 inhibitors attenuating tumor proliferation. We eval...

    Kenji Shoda, Shohei Tsuji, Shinsuke Nakamura in Cellular and Molecular Neurobiology (2023)

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    NMDA receptor signaling induces the chemoresistance of temozolomide via upregulation of MGMT expression in glioblastoma cells

    The alkylating agent temozolomide (TMZ) has a significant impact on the prognosis of glioblastoma (GBM) patients. Therefore, maximizing TMZ efficacy is important for GBM treatment. Many reports have shown that...

    Shohei Tsuji, Shinsuke Nakamura, Kenji Shoda, Tetsuya Yamada in Journal of Neuro-Oncology (2022)

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    Deferasirox, a trivalent iron chelator, ameliorates neuronal damage in hemorrhagic stroke models

    Intracranial hemorrhage (ICH) is a devastating disease with high mortality and morbidity. After ICH, iron released from the hematoma plays a crucial role in secondary brain injury. Deferasirox (DFR) is a triva...

    Takahiko Imai, Shohei Tsuji in Naunyn-Schmiedeberg's Archives of Pharmaco… (2021)

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    NS5A-P32 deletion as a factor involved in virologic failure in patients receiving glecaprevir and pibrentasvir

    This study sought to clarify the factors involved in virologic failure in patients with HCV receiving retreatment with glecaprevir/pibrentasvir (GLE/PIB) in real-world practice.

    Hayato Uemura, Yoshihito Uchida, Jun-ichi Kouyama in Journal of Gastroenterology (2019)