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  1. Article

    Open Access

    Novel nanographene oxide-calcium phosphate cement inhibits Enterococcus faecalis biofilm and supports dental pulp stem cells

    Enterococcus faecalis (E. faecalis) is the most recovered species from the root canals after failed root canal treatment. Calcium phosphate bone cement (CPC) scaffold is promising for applications in endodontic t...

    Shizhou Wu, Michael D. Weir, Lei Lei in Journal of Orthopaedic Surgery and Research (2021)

  2. Article

    Open Access

    Antisense yycG modulates the susceptibility of Staphylococcus aureus to hydrogen peroxide via the sarA

    The infectious pathogen Staphylococcus aureus (S. aureus) is primarily associated with osteomyelitis. Hydrogen peroxide drainage is an effective antimicrobial treatment that has been adopted to combat S. aureus i...

    Shizhou Wu, Yunjie Liu, Lei Lei, Hui Zhang in BMC Microbiology (2021)

  3. Article

    Open Access

    Virulence of methicillin-resistant Staphylococcus aureus modulated by the YycFG two-component pathway in a rat model of osteomyelitis

    Methicillin-resistant Staphylococcus aureus (MRSA) strains present an urgent medical problem in osteomyelitis cases. Our previous study indicated that the YycFG two-component regulatory pathway is associated with...

    Shizhou Wu, Yunjie Liu, Lei Lei, Hui Zhang in Journal of Orthopaedic Surgery and Research (2019)

  4. Article

    Open Access

    Nano-graphene oxide improved the antibacterial property of antisense yycG RNA on Staphylococcus aureus

    Staphylococcus aureus (S. aureus) has the potential to opportunistically cause infectious diseases, including osteomyelitis, skin infections, pneumonia, and diarrhea. We previously reported that ASyycG RNA reduce...

    Shizhou Wu, Yunjie Liu, Hui Zhang, Lei Lei in Journal of Orthopaedic Surgery and Research (2019)

  5. Article

    Open Access

    Staphylococcus aureus biofilm organization modulated by YycFG two-component regulatory pathway

    Staphylococcus aureus (S. aureus) infection accounts for more than 50% of the osteomyelitis cases. Currently, methicillin-resistant S. aureus (MRSA) strains present an urgent medical problem. The YycFG two-compon...

    Shizhou Wu, Fuguo Huang, Hui Zhang, Lei Lei in Journal of Orthopaedic Surgery and Research (2019)