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9 Result(s)

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  1. No Access

    Article

    Transcription and RNA interference in the formation of heterochromatin

    Transcription in heterochromatin seems to be an oxymoron — surely the 'silenced' form of chromatin should not be transcribed. But there have been frequent reports of low-level transcription in heterochromatic ...

    Shiv I. S. Grewal, Sarah C. R. Elgin in Nature (2007)

  2. No Access

    Article

    Host genome surveillance for retrotransposons by transposon-derived proteins

    Transposable elements and their remnants constitute a substantial fraction of eukaryotic genomes. Host genomes have evolved defence mechanisms, including chromatin modifications and RNA interference, to regula...

    Hugh P. Cam, Ken-ichi Noma, Hirotaka Ebina, Henry L. Levin, Shiv I. S. Grewal in Nature (2008)

  3. No Access

    Article

    Cell cycle control of centromeric repeat transcription and heterochromatin assembly

    RNA polymerase II transcribes heterochromatic repeat sequences preferentially during S-phase of the cell cycle, a timing that is enforced by heterochromatin restricting RNAPII access. Chromatin modifying enzym...

    Ee Sin Chen, Ke Zhang, Estelle Nicolas, Hugh P. Cam, Martin Zofall… in Nature (2008)

  4. No Access

    Article

    Histone H2A.Z cooperates with RNAi and heterochromatin factors to suppress antisense RNAs

    Unregulated transcription of antisense RNAs is potentially deleterious to a cell because sense–antisense pairing could affect gene expression. In this study, Zofall et al. examine how antisense transcription is h...

    Martin Zofall, Tamás Fischer, Ke Zhang, Ming Zhou, Bowen Cui, Timothy D. Veenstra… in Nature (2009)

  5. No Access

    Article

    RNAi triggered by specialized machinery silences developmental genes and retrotransposons

    In the fission yeast Schizosaccharomyces pombe RNA interference (RNAi) machinery promotes heterochromatin assembly and silencing of centromeric repeats; here it is shown that RNAi participates in silencing other ...

    Soichiro Yamanaka, Sameet Mehta, Francisca E. Reyes-Turcu, Fanglei Zhuang… in Nature (2013)

  6. No Access

    Article

    Cohesin-dependent globules and heterochromatin shape 3D genome architecture in S. pombe

    Genome-wide chromatin conformation capture (Hi-C) is used to investigate three-dimensional genome organization in Schizosaccharomyces pombe; small domains of chromatin interact locally on chromosome arms to form ...

    Takeshi Mizuguchi, Geoffrey Fudenberg, Sameet Mehta, Jon-Matthew Belton… in Nature (2014)

  7. No Access

    Article

    Untimely expression of gametogenic genes in vegetative cells causes uniparental disomy

    Uniparental disomy in fission yeast is triggered by aberrant expression of gametogenic genes in vegetative cells, and is associated with the activation of meiotic cohesin Rec8 in cells with defects in the RNA ...

    H. Diego Folco, Venkata R. Chalamcharla, Tomoyasu Sugiyama, Gobi Thillainadesan… in Nature (2017)

  8. Article

    Open Access

    A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing

    Gene regulatory mechanisms rely on a complex network of RNA processing factors to prevent untimely gene expression. In fission yeast, the highly conserved ortholog of human ERH, called Erh1, interacts with the...

    Guodong **e, Tommy V. Vo, Gobi Thillainadesan, Sahana Holla… in Nature Communications (2019)

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  9. Article

    Open Access

    Conserved protein Pir2ARS2 mediates gene repression through cryptic introns in lncRNAs

    Long non-coding RNAs (lncRNAs) are components of epigenetic control mechanisms that ensure appropriate and timely gene expression. The functions of lncRNAs are often mediated through associated gene regulatory...

    Gobi Thillainadesan, Hua **ao, Sahana Holla, Jothy Dhakshnamoorthy… in Nature Communications (2020)

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