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Article
Comparative efficacy and safety of combination therapy with infliximab for Crohn’s disease: a systematic review and network meta-analysis
There is not enough information to position medications for the treatment of Crohn’s disease (CD). Therefore, using a network meta-analysis and systematic review, we evaluated the efficacy and safety of combin...
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Article
Force model of freeform surface multi-axis machining with fillet end mill based on analytical contact analysis
In the multi-axis machining of freeform surface, compared with ball end mill, the fillet end mill has higher machining efficiency under the same residual height and has been widely used. As the most important ...
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Article
LncRNA HLA-F-AS1 promotes colorectal cancer metastasis by inducing PFN1 in colorectal cancer-derived extracellular vesicles and mediating macrophage polarization
Colorectal cancer (CRC) is a prevalent malignancy with high incidence and low 5-year survival. Long non-coding RNAs (lncRNAs), a kind of specific RNA transcript, are increasingly implicated in tumor growth, me...
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Article
Open AccessExtracellular vesicles-derived microRNA-222 promotes immune escape via interacting with ATF3 to regulate AKT1 transcription in colorectal cancer
Immunotherapy has been recently established as a new direction for the treatment of colorectal cancer (CRC), a gastrointestinal cancer. In this investigation, we aimed to expound how the posttranscriptional re...
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Article
Modal parameter identification of general cutter based on milling stability theory
In the field of CNC milling, chatter has been a hot research topic, which is related to machining quality, precision and cost. Stability lobe diagram (SLD) reflects the vibration of the machining system under ...
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Article
Mechanical modeling of five-axis single root clean-up machining of complex surface
Root clean-up machining is an important process for five-axis machining of complex curved surface parts. Subjected to harsh cutting conditions and lack of analysis of cutting force, single root clean-up machin...
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Article
An identification model of cutting force coefficients for five-axis ball-end milling
Five-axis ball-end milling is widely used in energy, ship, aerospace, and other fields. As one of the difficulties in milling research, milling force is often critical to the processing efficiency and quality ...